TY - JOUR
T1 - Gerbilline cholesteatoma development Part I
T2 - Epithelial migration pattern and rate on the gerbil tympanic membrane: Comparisons with human and guinea pig
AU - Tinling, Steven P.
AU - Chole, Richard A.
N1 - Funding Information:
Supported in part by grants from the Deafness Research Foundation and NIH Grant R01-NS21079.
PY - 2006/5
Y1 - 2006/5
N2 - Objective: To determine the migration rate and pattern for keratin on the tympanic membrane (TM) of the gerbil and guinea pig in comparison to human data and determine which species is an appropriate model for investigating the relationship of epithelial clearance to cholesteatoma formation. Study design and setting: Ink drops were placed on the TM and their locations plotted daily. Results: Gerbils demonstrated a radial migration pattern away from the umbo, identical to that reported for humans, although the rate was 0.32 mm/day-3 times the human rate of 0.1 mm/day. Guinea pigs were significantly different from gerbils and humans, with a rate of 0.79 mm/day and a pattern of superior/inferior migration without anterior-posterior movement. Conclusion: Gerbils more closely resemble humans in rate and pattern of epithelial migration. Significance: Gerbils represent the most appropriate model for determining the relationship between keratin migration and cholesteatoma formation.
AB - Objective: To determine the migration rate and pattern for keratin on the tympanic membrane (TM) of the gerbil and guinea pig in comparison to human data and determine which species is an appropriate model for investigating the relationship of epithelial clearance to cholesteatoma formation. Study design and setting: Ink drops were placed on the TM and their locations plotted daily. Results: Gerbils demonstrated a radial migration pattern away from the umbo, identical to that reported for humans, although the rate was 0.32 mm/day-3 times the human rate of 0.1 mm/day. Guinea pigs were significantly different from gerbils and humans, with a rate of 0.79 mm/day and a pattern of superior/inferior migration without anterior-posterior movement. Conclusion: Gerbils more closely resemble humans in rate and pattern of epithelial migration. Significance: Gerbils represent the most appropriate model for determining the relationship between keratin migration and cholesteatoma formation.
UR - http://www.scopus.com/inward/record.url?scp=33646087901&partnerID=8YFLogxK
U2 - 10.1016/j.otohns.2005.12.022
DO - 10.1016/j.otohns.2005.12.022
M3 - Article
C2 - 16647536
AN - SCOPUS:33646087901
SN - 0194-5998
VL - 134
SP - 788
EP - 793
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 5
ER -