TY - JOUR
T1 - Geogenomic segregation and temporal trends of human pathogenic Escherichia coli o157:H7, Washington, USA, 2005-2014
AU - Tarr, Gillian A.M.
AU - Shringi, Smriti
AU - Phipps, Amanda I.
AU - Besser, Thomas E.
AU - Mayer, Jonathan
AU - Oltean, Hanna N.
AU - Wakefield, Jon
AU - Tarr, Phillip I.
AU - Rabinowitz, Peter
N1 - Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2018/1
Y1 - 2018/1
N2 - The often-noted and persistent increased incidence of Escherichia coli O157:H7 infections in rural areas is not well understood. We used a cohort of E. coli O157:H7 cases reported in Washington, USA, during 2005-2014, along with phylogenomic characterization of the infecting isolates, to identify geographic segregation of and temporal trends in specific phylogenetic lineages of E. coli O157:H7. Kernel estimation and generalized additive models demonstrated that pathogen lineages were spatially segregated during the period of analysis and identified a focus of segregation spanning multiple, predominantly rural, counties for each of the main clinical lineages, Ib, IIa, and IIb. These results suggest the existence of local reservoirs from which humans are infected. We also noted a secular increase in the proportion of lineage IIa and IIb isolates. Spatial segregation by phylogenetic lineage offers the potential to identify local reservoirs and intervene to prevent continued transmission.
AB - The often-noted and persistent increased incidence of Escherichia coli O157:H7 infections in rural areas is not well understood. We used a cohort of E. coli O157:H7 cases reported in Washington, USA, during 2005-2014, along with phylogenomic characterization of the infecting isolates, to identify geographic segregation of and temporal trends in specific phylogenetic lineages of E. coli O157:H7. Kernel estimation and generalized additive models demonstrated that pathogen lineages were spatially segregated during the period of analysis and identified a focus of segregation spanning multiple, predominantly rural, counties for each of the main clinical lineages, Ib, IIa, and IIb. These results suggest the existence of local reservoirs from which humans are infected. We also noted a secular increase in the proportion of lineage IIa and IIb isolates. Spatial segregation by phylogenetic lineage offers the potential to identify local reservoirs and intervene to prevent continued transmission.
UR - http://www.scopus.com/inward/record.url?scp=85038856557&partnerID=8YFLogxK
U2 - 10.3201/eid2401.170851
DO - 10.3201/eid2401.170851
M3 - Article
C2 - 29260688
AN - SCOPUS:85038856557
SN - 1080-6040
VL - 24
SP - 32
EP - 39
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 1
ER -