TY - JOUR
T1 - Genomics and premalignant breast lesions
T2 - Clues to the development and progression of lobular breast cancer
AU - Mastracci, Teresa L.
AU - Boulos, Fouad I.
AU - Andrulis, I. L.Irene L.
AU - Lam, Wan L.
PY - 2007/11/16
Y1 - 2007/11/16
N2 - Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct lobular units of the breast, understanding the events involved in mammary gland development make it possible to recognize those events that, when altered, contribute to breast neoplasia. In this review we focus on lobular carcinomas, discussing the pathology, development, and progression of premalignant lobular lesions from a genomic point of view. We highlight studies utilizing genomic approaches and describe how these investigations have furthered our understanding of the complexity of premalignant breast lesions.
AB - Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct lobular units of the breast, understanding the events involved in mammary gland development make it possible to recognize those events that, when altered, contribute to breast neoplasia. In this review we focus on lobular carcinomas, discussing the pathology, development, and progression of premalignant lobular lesions from a genomic point of view. We highlight studies utilizing genomic approaches and describe how these investigations have furthered our understanding of the complexity of premalignant breast lesions.
UR - http://www.scopus.com/inward/record.url?scp=40349093128&partnerID=8YFLogxK
U2 - 10.1186/bcr1785
DO - 10.1186/bcr1785
M3 - Review article
C2 - 18036272
AN - SCOPUS:40349093128
SN - 1465-5411
VL - 9
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 6
M1 - 215
ER -