Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene

Béatrice Plougastel, Tania Jones, John Trowsdale

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

A cosmid containing the human NKG2A gene was isolated. The gene was partially sequenced, revealing 7 exons, including one 5' untranslated exon. The 54 base pair exon 5 was missing in the published cDNA clone NKG2B, consistent with the existence of different splicing. This was confirmed by reverse transcription-polymerase chain reaction of total RNA from normal lymphocytes. The NKG2A gene was mapped by FISH to chromosome 12p12.3-p13.1 in proximity to the CD69 and Prp genes. These data support the presence of a human lectin-like NK gene complex, analogous to the NK complex on mouse chromosome 6.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalImmunogenetics
Volume44
Issue number4
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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