Genomic scan for genes affecting body composition before after training in Caucasians from HERITAGE

Yvon C. Chagnon, Treva Rice, Louis Pérusse, Ingrid B. Borecki, My Anh Ho-Kim, Michel Lacaille, Chantal Paré, Luigi Bouchard, Jacques Gagnon, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D. C. Rao, Claude Bouchard

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


An autosomal genomewide search for genes related to body composition and its changes after a 20-wk endurance-exercise training program has been completed in the HERITAGE Family Study. Phenotypes included body mass index (BMI), sum of eight skinfold thicknesses, fat mass (FM), fat-free mass, percent body fat (%Fat), and plasma leptin levels. A maximum of 364 sib-pairs from 99 Caucasian families was studied with the use of 344 markers with single-point and multipoint linkage analyses. Evidence of significant linkage was observed for changes in fat-free mass with the S100A and the insulin-like growth factor I genes (P = 0.0001). Suggestive evidence (2.0 ≤ Lod < 3.0; 0.0001 < P ≤ 0.001) was also observed for the changes in FM and %Fat at 1q31 and 18q21-q23, in %Fat with the uncoupling protein 2 and 3 genes, and in BMI at 5q14-q21. At baseline, suggestive evidence was observed for BMI at 8q23-q24, 10p15, and 14q11; for FM at 14q11; and for plasma leptin levels with the low-density lipoprotein receptor gene. This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss.

Original languageEnglish
Pages (from-to)1777-1787
Number of pages11
JournalJournal of Applied Physiology
Issue number5
StatePublished - 2001


  • Body fat
  • Body mass index
  • Fat-free mass
  • Genetic
  • Genomewide search
  • Linkage


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