Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA

Keyphrases

• Clinical Outcomes 100%
• H3K27me3 100%
• Tumor Evolution 100%
• Cell-free DNA (cfDNA) 100%
• Malignant Peripheral Nerve Sheath Tumor (MPNST) 100%
• Genomic Patterns 100%
• Neurofibromatosis Type I 75%
• Neurofibromatosis Type 1 (NF-1) 75%
• Tumor Samples 50%
• Methylation Profiling 50%
• Immune Infiltration 50%
• Polycomb Repressive Complex 2 (PRC2) 50%
• Tumor 25%
• Somatic Copy number Alterations 25%
• Tumor Cells 25%
• Chromosomal Loss 25%
• Copy number Profiling 25%
• Exome Sequencing 25%
• Immune Cells 25%
• Cause of Death 25%
• Most Common Cause 25%
• Whole Genome 25%
• Tumor Predisposition Syndrome 25%
• Tumor Protein p53 (TP53) 25%
• Chromosome 8 25%
• Prognosis Prediction 25%
• Treatment-related 25%
• Genomic Instability 25%
• Soft Tissue Sarcoma 25%
• Transcriptomic Profiling 25%
• Biallelic mutations 25%
• Tumor-free 25%
• Cyclin-dependent Kinase Inhibitor 2A (CDKN2A) 25%
• Multi-regional 25%
• Biomarkers for Early Diagnosis 25%
• H3K27 Acetylation 25%
• Sample-free 25%
• Chromosome Doubling 25%

Biochemistry, Genetics and Molecular Biology

• Immunocompetent Cell 100%
• Methylation 100%
• Polycomb Repressive Complex 2 100%
• Genomics 100%
• Exome Sequencing 50%
• Genome Instability 50%
• Transcriptomics 50%
• Chromosome 8 50%
• Immunity 50%
• Cell Infiltration 50%