TY - JOUR
T1 - Genomic landscape of squamous cell carcinoma of the lung
AU - Morgensztern, Daniel
AU - Devarakonda, Siddhartha
AU - Govindan, Ramaswamy
PY - 2013
Y1 - 2013
N2 - Outcomes with standard therapy for patients with advanced squamous cell carcinoma (SQCC) of the lung have not improved significantly over the past decade using a predominantly empiric approach. Recent advances in pulmonary adenocarcinomas (ACs) have allowed the subdivision according to molecular subsets and the identification of specific molecular alterations that predict significant benefit from specific targeted therapies. Genomic alterations reported by The Cancer Genome Atlas (TCGA) Project identified a number of molecular targets that need to be studied systematically to improve the overall survival of patients with SQCC of the lung.
AB - Outcomes with standard therapy for patients with advanced squamous cell carcinoma (SQCC) of the lung have not improved significantly over the past decade using a predominantly empiric approach. Recent advances in pulmonary adenocarcinomas (ACs) have allowed the subdivision according to molecular subsets and the identification of specific molecular alterations that predict significant benefit from specific targeted therapies. Genomic alterations reported by The Cancer Genome Atlas (TCGA) Project identified a number of molecular targets that need to be studied systematically to improve the overall survival of patients with SQCC of the lung.
UR - http://www.scopus.com/inward/record.url?scp=84979835693&partnerID=8YFLogxK
U2 - 10.1200/EdBook_AM.2013.33.348
DO - 10.1200/EdBook_AM.2013.33.348
M3 - Review article
C2 - 23714544
AN - SCOPUS:84979835693
SN - 1548-8756
SP - 348
EP - 353
JO - American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting
JF - American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting
ER -