Genomic landscape of intracranial meningiomas

Wenya Linda Bi, Malak Abedalthagafi, Peleg Horowitz, Pankaj K. Agarwalla, Yu Mei, Ayal A. Aizer, Ryan Brewster, Gavin P. Dunn, Ossama Al-Mefty, Brian M. Alexander, Sandro Santagata, Rameen Beroukhim, Ian F. Dunn

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.

Original languageEnglish
Pages (from-to)525-535
Number of pages11
JournalJournal of neurosurgery
Volume125
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • Genomics
  • Meningioma
  • Molecular taxonomy
  • Oncology
  • Precision medicine
  • Targeted therapy
  • Tumor classification
  • Tumor progression

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