Abstract
Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.
Original language | English |
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Pages (from-to) | 525-535 |
Number of pages | 11 |
Journal | Journal of neurosurgery |
Volume | 125 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2016 |
Keywords
- Genomics
- Meningioma
- Molecular taxonomy
- Oncology
- Precision medicine
- Targeted therapy
- Tumor classification
- Tumor progression