Genomic landscape of intracranial meningiomas

Wenya Linda Bi, Malak Abedalthagafi, Peleg Horowitz, Pankaj K. Agarwalla, Yu Mei, Ayal A. Aizer, Ryan Brewster, Gavin P. Dunn, Ossama Al-Mefty, Brian M. Alexander, Sandro Santagata, Rameen Beroukhim, Ian F. Dunn

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.

Original languageEnglish
Pages (from-to)525-535
Number of pages11
JournalJournal of neurosurgery
Issue number3
StatePublished - Sep 2016


  • Genomics
  • Meningioma
  • Molecular taxonomy
  • Oncology
  • Precision medicine
  • Targeted therapy
  • Tumor classification
  • Tumor progression


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