Genomic landscape of cancer

Christopher J. Maher, Elaine R. Mardis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The study of cancer genomics has advanced rapidly during the last decade due to the development of next generation or massively parallel technology for DNA sequencing. The resulting knowledge is transforming the understanding of both inherited (germline) genetic susceptibility and the somatic changes in tumor tissue that drive abnormal growth and progression. The somatic alterations in tumor tissue vary depending on the type of cancer and its characteristic “genomic landscape.” New technologies have increased the speed and lowered the cost of DNA sequencing and have enabled high-volume characterization of RNA, DNA methylation, DNA-protein complexes, DNA conformation, and a host of other factors that, when altered, can contribute to the development and/or progression of the cancer. Technologic advances have greatly expanded research on somatic changes in tumor tissue, revealing both the singularity of individual cancer genomes and the commonality of genetic alterations that drive cancer in different tissues.

Original languageEnglish
Title of host publicationSchottenfeld and Fraumeni Cancer Epidemiology and Prevention, Fourth Edition
PublisherOxford University Press
Pages43-52
Number of pages10
ISBN (Electronic)9780190238667
DOIs
StatePublished - Jan 1 2017

Keywords

  • Cancer
  • Cancer genomics
  • DNA
  • Genome
  • Next generation sequencing
  • Tumor

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