TY - JOUR
T1 - Genomic imprinting and parent-of-origin effects on complex traits
AU - Lawson, Heather A.
AU - Cheverud, James M.
AU - Wolf, Jason B.
N1 - Funding Information:
H.A.L. is supported by the US National Institute of Diabetes and Digestive and Kidney Diseases of the US National Institutes of Health (awards K01DK095003 to H.A.L. and P30DK056341 to the Washington University School of Medicine Nutrition and Obesity Research Center). J.B.W. is supported by grant support from the UK Biotechnology and Biological Sciences Research Council (BBSRC).
PY - 2013/9
Y1 - 2013/9
N2 - Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it is inherited from the mother or the father. Several phenomena can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene expression associated with genomic imprinting. The development of new mapping approaches applied to the growing abundance of genomic data has demonstrated that imprinted genes can be important contributors to complex trait variation. Therefore, to understand the genetic architecture and evolution of complex traits, including complex diseases and traits of agricultural importance, it is crucial to account for these parent-of-origin effects. Here, we discuss patterns of phenotypic variation associated with imprinting, evidence supporting its role in complex trait variation and approaches for identifying its molecular signatures.
AB - Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it is inherited from the mother or the father. Several phenomena can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene expression associated with genomic imprinting. The development of new mapping approaches applied to the growing abundance of genomic data has demonstrated that imprinted genes can be important contributors to complex trait variation. Therefore, to understand the genetic architecture and evolution of complex traits, including complex diseases and traits of agricultural importance, it is crucial to account for these parent-of-origin effects. Here, we discuss patterns of phenotypic variation associated with imprinting, evidence supporting its role in complex trait variation and approaches for identifying its molecular signatures.
UR - http://www.scopus.com/inward/record.url?scp=84882448216&partnerID=8YFLogxK
U2 - 10.1038/nrg3543
DO - 10.1038/nrg3543
M3 - Review article
C2 - 23917626
AN - SCOPUS:84882448216
SN - 1471-0056
VL - 14
SP - 609
EP - 617
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 9
ER -