Genomic imprinting and parent-of-origin effects on complex traits

Heather A. Lawson, James M. Cheverud, Jason B. Wolf

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations

Abstract

Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it is inherited from the mother or the father. Several phenomena can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene expression associated with genomic imprinting. The development of new mapping approaches applied to the growing abundance of genomic data has demonstrated that imprinted genes can be important contributors to complex trait variation. Therefore, to understand the genetic architecture and evolution of complex traits, including complex diseases and traits of agricultural importance, it is crucial to account for these parent-of-origin effects. Here, we discuss patterns of phenotypic variation associated with imprinting, evidence supporting its role in complex trait variation and approaches for identifying its molecular signatures.

Original languageEnglish
Pages (from-to)609-617
Number of pages9
JournalNature Reviews Genetics
Volume14
Issue number9
DOIs
StatePublished - Sep 1 2013

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