Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing

Clément Collignon; Tucker Hansen; Colin Hercus; Marianna B. Ruzinova; Gabrielle Roth Guepin; Caroline Bonmati; Marie Thérèse Rubio; Pierre Feugier; Mélanie Gaudfrin; Hervé Sartelet; Marion Divoux; Marc Muller; Sharon Heath; Geoffrey L. Uy; David H. Spencer; David Y. Chen; Simona Pagliuca; Francesca Ferraro

doi:10.1038/s41408-025-01345-2

Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing

Clément Collignon, Tucker Hansen, Colin Hercus, Marianna B. Ruzinova, Gabrielle Roth Guepin, Caroline Bonmati, Marie Thérèse Rubio, Pierre Feugier, Mélanie Gaudfrin, Hervé Sartelet, Marion Divoux, Marc Muller, Sharon Heath, Geoffrey L. Uy, David H. Spencer, David Y. Chen, Simona Pagliuca, Francesca Ferraro

Research output: Contribution to journal › Letter › peer-review

Abstract

(Figure presented.)

Original language	English
Article number	136
Journal	Blood cancer journal
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41408-025-01345-2
State	Published - Dec 2025

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Collignon, C., Hansen, T., Hercus, C., Ruzinova, M. B., Roth Guepin, G., Bonmati, C., Rubio, M. T., Feugier, P., Gaudfrin, M., Sartelet, H., Divoux, M., Muller, M., Heath, S., Uy, G. L., Spencer, D. H., Chen, D. Y., Pagliuca, S., & Ferraro, F. (2025). Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing. Blood cancer journal, 15(1), Article 136. https://doi.org/10.1038/s41408-025-01345-2

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title = "Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing",

abstract = "(Figure presented.)",

author = "Cl{\'e}ment Collignon and Tucker Hansen and Colin Hercus and Ruzinova, \{Marianna B.\} and \{Roth Guepin\}, Gabrielle and Caroline Bonmati and Rubio, \{Marie Th{\'e}r{\`e}se\} and Pierre Feugier and M{\'e}lanie Gaudfrin and Herv{\'e} Sartelet and Marion Divoux and Marc Muller and Sharon Heath and Uy, \{Geoffrey L.\} and Spencer, \{David H.\} and Chen, \{David Y.\} and Simona Pagliuca and Francesca Ferraro",

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year = "2025",

month = dec,

doi = "10.1038/s41408-025-01345-2",

language = "English",

volume = "15",

journal = "Blood cancer journal",

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Collignon, C, Hansen, T, Hercus, C, Ruzinova, MB, Roth Guepin, G, Bonmati, C, Rubio, MT, Feugier, P, Gaudfrin, M, Sartelet, H, Divoux, M, Muller, M, Heath, S, Uy, GL , Spencer, DH , Chen, DY, Pagliuca, S & Ferraro, F 2025, 'Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing', Blood cancer journal, vol. 15, no. 1, 136. https://doi.org/10.1038/s41408-025-01345-2

TY - JOUR

T1 - Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing

AU - Collignon, Clément

AU - Hansen, Tucker

AU - Hercus, Colin

AU - Ruzinova, Marianna B.

AU - Roth Guepin, Gabrielle

AU - Bonmati, Caroline

AU - Rubio, Marie Thérèse

AU - Feugier, Pierre

AU - Gaudfrin, Mélanie

AU - Sartelet, Hervé

AU - Divoux, Marion

AU - Muller, Marc

AU - Heath, Sharon

AU - Uy, Geoffrey L.

AU - Spencer, David H.

AU - Chen, David Y.

AU - Pagliuca, Simona

AU - Ferraro, Francesca

PY - 2025/12

Y1 - 2025/12

N2 - (Figure presented.)

AB - (Figure presented.)

UR - https://www.scopus.com/pages/publications/105013461308

U2 - 10.1038/s41408-025-01345-2

DO - 10.1038/s41408-025-01345-2

M3 - Letter

C2 - 40804254

AN - SCOPUS:105013461308

SN - 2044-5385

VL - 15

JO - Blood cancer journal

JF - Blood cancer journal

IS - 1

M1 - 136

ER -

Genomic and immunogenomic profiling of extramedullary acute myeloid leukemia reveals actionable clonal branching and frequent immune editing

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