@article{6b0ff5154a654a9e83218d5650f4a86a,
title = "Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes",
abstract = "Microbial communities contain diverse bacteria that play important roles in every environment. Advances in sequencing and computational methodologies over the past decades have illuminated the phylogenetic and functional diversity of microbial communities from diverse habitats. Among the activities encoded in microbiomes are the abilities to synthesize and resist small molecules, yielding antimicrobial activity. These functions are of particular interest when viewed in light of the public health emergency posed by the increase in clinical antimicrobial resistance and the dwindling antimicrobial discovery and approval pipeline, and given the intimate ecological and evolutionary relationship between antimicrobial biosynthesis and resistance. Here, we review genomic and functional methods that have been developed for accessing the antimicrobial biosynthesis and resistance capacity of microbiomes and highlight outstanding examples of their applications.",
keywords = "antimicrobial resistance, antimicrobials, metagenomics, microbiome",
author = "Boahemaa Adu-Oppong and Gasparrini, {Andrew J.} and Gautam Dantas",
note = "Funding Information: This work was supported in part by grants to G.D. from the National Institutes of Health (NIH) Director's New Innovator Award (http://commonfund.nih.gov/newinnovator/), the National Institute of Diabetes and Digestive and Kidney Diseases (http://www.niddk.nih.gov/), the National Institute of General Medical Sciences (NIGMS: http://www.nigms.nih.gov/), and the National Institute of Allergy and Infectious Diseases (https://www.niaid.nih.gov/) of the NIH under Award Numbers DP2DK098089, R01GM099538, and R01AI123394. B.A. is a National Science Foundation graduate research fellow (Award Number DGE-1143945). A.J.G. received support from an NIGMS training grant through Award Number T32 GM007067. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. Publisher Copyright: {\textcopyright} 2016 New York Academy of Sciences.",
year = "2017",
month = jan,
day = "1",
doi = "10.1111/nyas.13257",
language = "English",
volume = "1388",
pages = "42--58",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
number = "1",
}