Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer

Varun Chalivendra, Krishna Latha Kanchi, Michael D. Onken, Ashley E. Winkler, Elaine Mardis, Ravindra Uppaluri

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

To investigate the molecular basis underlying aggressive behavior in oral squamous cell carcinoma (OSCC), our laboratory developed a carcinogen-induced mouse oral cancer (MOC) cell line model that encompasses the growth and metastasis spectrum of its human counterpart. We performed next-generation sequencing (NGS) and gene expression microarray profiles to explore the genomic and transcriptional backgrounds of the differential MOC line phenotypes, as well as, the cross-species relevance of the model. Here we describe the comparative analysis of NGS (. www.ncbi.nlm.nih.gov/biosample?LinkName=bioproject_biosample_all&from_uid=247825) and expression microarray (. www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50041) data from the MOC lines and corresponding human data, as described in our recent publication [1].

Original languageEnglish
Pages (from-to)61-62
Number of pages2
JournalGenomics Data
Volume3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Comparative microarrays
  • Gene signatures
  • Metastasis
  • Mouse models

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