Genomewide Association Scan of a Mortality Associated Endophenotype for a Long and Healthy Life in the Long Life Family Study

Jatinder Singh, Ryan L. Minster, Nicole Schupf, Aldi Kraja, Yongmei Liu, Kaare Christensen, Anne B. Newman, Candace M. Kammerer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity. Methods Using data from the Long Life Family Study, we performed genomewide association analyses on an endophenotype construct, LF1, comprising a linear combination of traits across health domains. LF1 primarily reflected traits from the pulmonary and physical activity domains. Results We detected a significant association between LF1 and a locus on chromosome 10p15 (p-value = 4.65 × 10 ' '8) and suggestive evidence (p-value < 5 × 10 ' '6) for association on chromosomes 1, 2, 8, 12, 15, 18, and 22. Using data from the Health, Aging and Body Composition Study, we subsequently replicated the association for the 1p13 region near the NBPF6 locus (p-value = 3.65 × 10 ' '4). Conclusions Our analyses indicate that loci influencing a healthy aging endophenotype construct predominantly comprised of pulmonary and physical function domains may be located on chromosome 1p13 near the NBPF6 locus. Further investigation of this possible locus and other suggestive loci may reveal novel biological pathways that influence healthy aging.

Original languageEnglish
Pages (from-to)1411-1416
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume72
Issue number10
DOIs
StatePublished - Oct 1 2017

Keywords

  • Human genetics
  • Longevity
  • Mortality
  • Motor activity
  • Respiratory function

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