Genome-wide search for Schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortium

C. Robert Cloninger, Charles A. Kaufmann, Stephen V. Faraone, Dolores Malaspina, Dragan M. Svrakic, Jill Harkavy-Friedman, Brian K. Suarez, Tara C. Matise, David Shore, Hang Lee, Carol L. Hampe, Debra Wynne, Caroline Drain, Paul D. Markel, Christopher T. Zambuto, Karin Schmitt, Ming T. Tsuang

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Schizophrenia has a complex pattern of inheritance, indicative of interactions among multiple genes and environmental factors. The detection and replication of specific susceptibility loci for such complex disorders are facilitated by the availability of large samples of affected sib pairs and their nuclear families, along with standardized assessment and systematic ascertainment procedures. The NIMH Genetics Initiative on Schizophrenia, a multisite collaborative study, was established as a national resource with a centralized clinical data base and cell repository. The Millennium Schizophrenia Consortium has completed a genome-wide scan to detect susceptibility loci for schizophrenia in 244 individuals from the nuclear families of 92 independent pairs of schizophrenic sibs ascertained by the NIMH Genetics Initiative. The 459 marker loci used in the scan were spaced at 10-cM intervals on average. Individuals of African descent were higher than those of European descent in their average heterozygosity (79% vs. 76%, P < .0001) and number of alleles per marker (9.2 vs. 8.4, P < .0001). Also, the allele frequencies of 73% of the marker loci differed significantly (P < .01) between individuals of European and African ancestry. However, regardless of ethnic background, this sample was largely comprised of schizophrenics with more than a decade of psychosis associated with pervasive social and occupational impairment.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number4
DOIs
StatePublished - Jul 10 1998

Keywords

  • Family study
  • Genetics
  • Linkage
  • Schizophrenia

Fingerprint Dive into the research topics of 'Genome-wide search for Schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortium'. Together they form a unique fingerprint.

  • Cite this

    Cloninger, C. R., Kaufmann, C. A., Faraone, S. V., Malaspina, D., Svrakic, D. M., Harkavy-Friedman, J., Suarez, B. K., Matise, T. C., Shore, D., Lee, H., Hampe, C. L., Wynne, D., Drain, C., Markel, P. D., Zambuto, C. T., Schmitt, K., & Tsuang, M. T. (1998). Genome-wide search for Schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortium. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(4), 275-281. https://doi.org/10.1002/(SICI)1096-8628(19980710)81:4<275::AID-AJMG1>3.0.CO;2-T