Genome-wide search for genes affecting the risk for alcohol dependence

Theodore Reich; Howard J. Edenberg; Alison Goate; Jeff T. Williams; John P. Rice; Paul Van Eerdewegh; Tatiana Foroud; Victor Hesselbrock; Marc A. Schuckit; Kathleen Bucholz; Bernice Porjesz; Ting Kai Li; P. Michael Conneally; John I. Nurnberger; Jay A. Tischfield; Raymond R. Crowe; C. Robert Cloninger; William Wu; Shantia Shears; Kristie Carr; Candice Crose; Chris Willig; Henri Begleiter

doi:10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T

Genome-wide search for genes affecting the risk for alcohol dependence

Theodore Reich, Howard J. Edenberg, Alison Goate, Jeff T. Williams, John P. Rice, Paul Van Eerdewegh, Tatiana Foroud, Victor Hesselbrock, Marc A. Schuckit, Kathleen Bucholz, Bernice Porjesz, Ting Kai Li, P. Michael Conneally, John I. Nurnberger, Jay A. Tischfield, Raymond R. Crowe, C. Robert Cloninger, William Wu, Shantia Shears, Kristie CarrCandice Crose, Chris Willig, Henri Begleiter

Research output: Contribution to journal › Article › peer-review

658 Scopus citations

Abstract

Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six- center collaborative study to identify susceptibility loci for alcohol dependence. A genome-wide screen examined 291 markers in 987 individuals from 105 families. Two-point and multipoint nonparametric linkage analyses were performed to detect susceptibility loci for alcohol dependence. Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.

Original language	English
Pages (from-to)	207-215
Number of pages	9
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	81
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T
State	Published - May 8 1998

Keywords

Alcohol dependence
Alcoholism
Genetic susceptibility
Genome screening
Linkage analysis

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10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T

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Reich, T., Edenberg, H. J., Goate, A., Williams, J. T., Rice, J. P., Van Eerdewegh, P., Foroud, T., Hesselbrock, V., Schuckit, M. A., Bucholz, K., Porjesz, B., Li, T. K., Conneally, P. M., Nurnberger, J. I., Tischfield, J. A., Crowe, R. R., Cloninger, C. R., Wu, W., Shears, S., ... Begleiter, H. (1998). Genome-wide search for genes affecting the risk for alcohol dependence. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(3), 207-215. https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T

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title = "Genome-wide search for genes affecting the risk for alcohol dependence",

abstract = "Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six- center collaborative study to identify susceptibility loci for alcohol dependence. A genome-wide screen examined 291 markers in 987 individuals from 105 families. Two-point and multipoint nonparametric linkage analyses were performed to detect susceptibility loci for alcohol dependence. Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.",

keywords = "Alcohol dependence, Alcoholism, Genetic susceptibility, Genome screening, Linkage analysis",

author = "Theodore Reich and Edenberg, {Howard J.} and Alison Goate and Williams, {Jeff T.} and Rice, {John P.} and {Van Eerdewegh}, Paul and Tatiana Foroud and Victor Hesselbrock and Schuckit, {Marc A.} and Kathleen Bucholz and Bernice Porjesz and Li, {Ting Kai} and Conneally, {P. Michael} and Nurnberger, {John I.} and Tischfield, {Jay A.} and Crowe, {Raymond R.} and Cloninger, {C. Robert} and William Wu and Shantia Shears and Kristie Carr and Candice Crose and Chris Willig and Henri Begleiter",

year = "1998",

month = may,

day = "8",

doi = "10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T",

language = "English",

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Reich, T, Edenberg, HJ, Goate, A, Williams, JT, Rice, JP, Van Eerdewegh, P, Foroud, T, Hesselbrock, V, Schuckit, MA, Bucholz, K, Porjesz, B, Li, TK, Conneally, PM, Nurnberger, JI, Tischfield, JA, Crowe, RR, Cloninger, CR, Wu, W, Shears, S, Carr, K, Crose, C, Willig, C & Begleiter, H 1998, 'Genome-wide search for genes affecting the risk for alcohol dependence', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 3, pp. 207-215. https://doi.org/10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T

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T1 - Genome-wide search for genes affecting the risk for alcohol dependence

AU - Reich, Theodore

AU - Edenberg, Howard J.

AU - Goate, Alison

AU - Williams, Jeff T.

AU - Rice, John P.

AU - Van Eerdewegh, Paul

AU - Foroud, Tatiana

AU - Hesselbrock, Victor

AU - Schuckit, Marc A.

AU - Bucholz, Kathleen

AU - Porjesz, Bernice

AU - Li, Ting Kai

AU - Conneally, P. Michael

AU - Nurnberger, John I.

AU - Tischfield, Jay A.

AU - Crowe, Raymond R.

AU - Cloninger, C. Robert

AU - Wu, William

AU - Shears, Shantia

AU - Carr, Kristie

AU - Crose, Candice

AU - Willig, Chris

AU - Begleiter, Henri

PY - 1998/5/8

Y1 - 1998/5/8

N2 - Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six- center collaborative study to identify susceptibility loci for alcohol dependence. A genome-wide screen examined 291 markers in 987 individuals from 105 families. Two-point and multipoint nonparametric linkage analyses were performed to detect susceptibility loci for alcohol dependence. Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.

AB - Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six- center collaborative study to identify susceptibility loci for alcohol dependence. A genome-wide screen examined 291 markers in 987 individuals from 105 families. Two-point and multipoint nonparametric linkage analyses were performed to detect susceptibility loci for alcohol dependence. Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.

KW - Alcohol dependence

KW - Alcoholism

KW - Genetic susceptibility

KW - Genome screening

KW - Linkage analysis

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DO - 10.1002/(SICI)1096-8628(19980508)81:3<207::AID-AJMG1>3.0.CO;2-T

M3 - Article

C2 - 9603606

AN - SCOPUS:0032496312

SN - 1552-4841

VL - 81

SP - 207

EP - 215

JO - American Journal of Medical Genetics - Neuropsychiatric Genetics

JF - American Journal of Medical Genetics - Neuropsychiatric Genetics

IS - 3

ER -

Genome-wide search for genes affecting the risk for alcohol dependence

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Keywords

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