TY - JOUR
T1 - Genome-wide association uncovers shared genetic effects among personality traits and mood states
AU - Luciano, Michelle
AU - Huffman, Jennifer E.
AU - Arias-Vásquez, Alejandro
AU - Vinkhuyzen, Anna A.E.
AU - Middeldorp, Christel M.
AU - Giegling, Ina
AU - Payton, Antony
AU - Davies, Gail
AU - Zgaga, Lina
AU - Janzing, Joost
AU - Ke, Xiayi
AU - Galesloot, Tessel
AU - Hartmann, Annette M.
AU - Ollier, William
AU - Tenesa, Albert
AU - Hayward, Caroline
AU - Verhagen, Maaike
AU - Montgomery, Grant W.
AU - Hottenga, Jouke Jan
AU - Konte, Bettina
AU - Starr, John M.
AU - Vitart, Veronique
AU - Vos, Pieter E.
AU - Madden, Pamela A.F.
AU - Willemsen, Gonneke
AU - Konnerth, Heike
AU - Horan, Michael A.
AU - Porteous, David J.
AU - Campbell, Harry
AU - Vermeulen, Sita H.
AU - Heath, Andrew C.
AU - Wright, Alan
AU - Polasek, Ozren
AU - Kovacevic, Sanja B.
AU - Hastie, Nicholas D.
AU - Franke, Barbara
AU - Boomsma, Dorret I.
AU - Martin, Nicholas G.
AU - Rujescu, Dan
AU - Wilson, James F.
AU - Buitelaar, Jan
AU - Pendleton, Neil
AU - Rudan, Igor
AU - Deary, Ian J.
PY - 2012/9
Y1 - 2012/9
N2 - Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n=6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527-6,032). Suggestive association (P=8×10-8) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P<6.09×10-6) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress. An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. Gene-based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (P<0.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits. © 2012 Wiley Periodicals, Inc.
AB - Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n=6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n=527-6,032). Suggestive association (P=8×10-8) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P<6.09×10-6) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress. An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. Gene-based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (P<0.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits. © 2012 Wiley Periodicals, Inc.
KW - Anxiety
KW - Depression
KW - Extraversion
KW - GWAS
KW - Neuroticism
UR - http://www.scopus.com/inward/record.url?scp=84864945763&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.32072
DO - 10.1002/ajmg.b.32072
M3 - Article
C2 - 22628180
AN - SCOPUS:84864945763
SN - 1552-4841
VL - 159 B
SP - 684
EP - 695
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 6
ER -