Genome-wide Association Study of Smoking Initiation and Current Smoking

Jacqueline M. Vink; August B. Smit; Eco J.C. de Geus; Patrick Sullivan; Gonneke Willemsen; Jouke Jan Hottenga; Johannes H. Smit; Witte J. Hoogendijk; Frans G. Zitman; Leena Peltonen; Jaakko Kaprio; Nancy L. Pedersen; Patrik K. Magnusson; Tim D. Spector; Kirsten Ohm Kyvik; Katherine I. Morley; Andrew C. Heath; Nicholas G. Martin; Rudi G.J. Westendorp; P. Eline Slagboom; Henning Tiemeier; Albert Hofman; Andre G. Uitterlinden; Yurii S. Aulchenko; Najaf Amin; Cornelia van Duijn; Brenda W. Penninx; Dorret I. Boomsma

doi:10.1016/j.ajhg.2009.02.001

Genome-wide Association Study of Smoking Initiation and Current Smoking

Jacqueline M. Vink, August B. Smit, Eco J.C. de Geus, Patrick Sullivan, Gonneke Willemsen, Jouke Jan Hottenga, Johannes H. Smit, Witte J. Hoogendijk, Frans G. Zitman, Leena Peltonen, Jaakko Kaprio, Nancy L. Pedersen, Patrik K. Magnusson, Tim D. Spector, Kirsten Ohm Kyvik, Katherine I. Morley, Andrew C. Heath, Nicholas G. Martin, Rudi G.J. Westendorp, P. Eline SlagboomHenning Tiemeier, Albert Hofman, Andre G. Uitterlinden, Yurii S. Aulchenko, Najaf Amin, Cornelia van Duijn, Brenda W. Penninx, Dorret I. Boomsma

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Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

Original language	English
Pages (from-to)	367-379
Number of pages	13
Journal	American journal of human genetics
Volume	84
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2009.02.001
State	Published - Mar 13 2009

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Vink, J. M., Smit, A. B., de Geus, E. J. C., Sullivan, P., Willemsen, G., Hottenga, J. J., Smit, J. H., Hoogendijk, W. J., Zitman, F. G., Peltonen, L., Kaprio, J., Pedersen, N. L., Magnusson, P. K., Spector, T. D., Kyvik, K. O., Morley, K. I., Heath, A. C., Martin, N. G., Westendorp, R. G. J., ... Boomsma, D. I. (2009). Genome-wide Association Study of Smoking Initiation and Current Smoking. American journal of human genetics, 84(3), 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

@article{7d834aaa9a1c4cff9f62dbca860551ea,

title = "Genome-wide Association Study of Smoking Initiation and Current Smoking",

abstract = "For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.",

author = "Vink, {Jacqueline M.} and Smit, {August B.} and {de Geus}, {Eco J.C.} and Patrick Sullivan and Gonneke Willemsen and Hottenga, {Jouke Jan} and Smit, {Johannes H.} and Hoogendijk, {Witte J.} and Zitman, {Frans G.} and Leena Peltonen and Jaakko Kaprio and Pedersen, {Nancy L.} and Magnusson, {Patrik K.} and Spector, {Tim D.} and Kyvik, {Kirsten Ohm} and Morley, {Katherine I.} and Heath, {Andrew C.} and Martin, {Nicholas G.} and Westendorp, {Rudi G.J.} and Slagboom, {P. Eline} and Henning Tiemeier and Albert Hofman and Uitterlinden, {Andre G.} and Aulchenko, {Yurii S.} and Najaf Amin and {van Duijn}, Cornelia and Penninx, {Brenda W.} and Boomsma, {Dorret I.}",

note = "Funding Information: We acknowledge support from The Netherlands Organization for Scientific Research (NWO) and The Netherlands Organization for Health Research and Development (ZonMW) (funding numbers 904-61-090, 904-61-193, 480-04-004, 400-05-717), NWO Genomics (SPI 56-464-14192), the Geestkracht program (10-000-1002), matching funds from universities and mental health care institutes involved in The Netherlands Study of Depression and Anxiety (NESDA), the Centre for Neurogenomics and Cognitive Research (CNCR-VU), and the European Union (EU)/Quality of Life program (Generic) RTD actions (QLRT) (2001-01254). J.M.V. is financially supported by NWO (VENI 451-06-004). Genotyping was funded by the Genetic Association Information Network (GAIN) of the Foundation for the U.S. National Institutes of Health, and analysis was supported by grants from GAIN and the U.S. National Institute of Mental Health (NIMH) (MH081802). Permutation tests were carried out on the Genetic Cluster Computer, which is financially supported by NWO (480-05-003). P.F.S. was supported by grants MH074027 and MH077139 from NIMH. J.K. and L.P. are supported by the Academy of Finland Centre of Excellence in Complex Disease Genetics. We would like to express our thanks to G.W. Montgomery for supervising sample preparation of the Australian sample. The Twins UK study is also funded by the Wellcome Trust, an NIHR fellowship, and an NIHR Biomedical Research Centre grant to Guys' and St. Thomas' Hospitals and King's College London. The Leiden Study was funded by grants from SenterNovem (IDE1014 and IGE5007) and The Netherlands Genomics Initiative (NGI)/NOW (05040202 and 050-060-810). ",

year = "2009",

month = mar,

day = "13",

doi = "10.1016/j.ajhg.2009.02.001",

language = "English",

volume = "84",

pages = "367--379",

journal = "American journal of human genetics",

issn = "0002-9297",

number = "3",

}

Vink, JM, Smit, AB, de Geus, EJC, Sullivan, P, Willemsen, G, Hottenga, JJ, Smit, JH, Hoogendijk, WJ, Zitman, FG, Peltonen, L, Kaprio, J, Pedersen, NL, Magnusson, PK, Spector, TD, Kyvik, KO, Morley, KI, Heath, AC, Martin, NG, Westendorp, RGJ, Slagboom, PE, Tiemeier, H, Hofman, A, Uitterlinden, AG, Aulchenko, YS, Amin, N, van Duijn, C, Penninx, BW & Boomsma, DI 2009, 'Genome-wide Association Study of Smoking Initiation and Current Smoking', American journal of human genetics, vol. 84, no. 3, pp. 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

TY - JOUR

T1 - Genome-wide Association Study of Smoking Initiation and Current Smoking

AU - Vink, Jacqueline M.

AU - Smit, August B.

AU - de Geus, Eco J.C.

AU - Sullivan, Patrick

AU - Willemsen, Gonneke

AU - Hottenga, Jouke Jan

AU - Smit, Johannes H.

AU - Hoogendijk, Witte J.

AU - Zitman, Frans G.

AU - Peltonen, Leena

AU - Kaprio, Jaakko

AU - Pedersen, Nancy L.

AU - Magnusson, Patrik K.

AU - Spector, Tim D.

AU - Kyvik, Kirsten Ohm

AU - Morley, Katherine I.

AU - Heath, Andrew C.

AU - Martin, Nicholas G.

AU - Westendorp, Rudi G.J.

AU - Slagboom, P. Eline

AU - Tiemeier, Henning

AU - Hofman, Albert

AU - Uitterlinden, Andre G.

AU - Aulchenko, Yurii S.

AU - Amin, Najaf

AU - van Duijn, Cornelia

AU - Penninx, Brenda W.

AU - Boomsma, Dorret I.

N1 - Funding Information: We acknowledge support from The Netherlands Organization for Scientific Research (NWO) and The Netherlands Organization for Health Research and Development (ZonMW) (funding numbers 904-61-090, 904-61-193, 480-04-004, 400-05-717), NWO Genomics (SPI 56-464-14192), the Geestkracht program (10-000-1002), matching funds from universities and mental health care institutes involved in The Netherlands Study of Depression and Anxiety (NESDA), the Centre for Neurogenomics and Cognitive Research (CNCR-VU), and the European Union (EU)/Quality of Life program (Generic) RTD actions (QLRT) (2001-01254). J.M.V. is financially supported by NWO (VENI 451-06-004). Genotyping was funded by the Genetic Association Information Network (GAIN) of the Foundation for the U.S. National Institutes of Health, and analysis was supported by grants from GAIN and the U.S. National Institute of Mental Health (NIMH) (MH081802). Permutation tests were carried out on the Genetic Cluster Computer, which is financially supported by NWO (480-05-003). P.F.S. was supported by grants MH074027 and MH077139 from NIMH. J.K. and L.P. are supported by the Academy of Finland Centre of Excellence in Complex Disease Genetics. We would like to express our thanks to G.W. Montgomery for supervising sample preparation of the Australian sample. The Twins UK study is also funded by the Wellcome Trust, an NIHR fellowship, and an NIHR Biomedical Research Centre grant to Guys' and St. Thomas' Hospitals and King's College London. The Leiden Study was funded by grants from SenterNovem (IDE1014 and IGE5007) and The Netherlands Genomics Initiative (NGI)/NOW (05040202 and 050-060-810).

PY - 2009/3/13

Y1 - 2009/3/13

N2 - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

AB - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

UR - http://www.scopus.com/inward/record.url?scp=61849154183&partnerID=8YFLogxK

U2 - 10.1016/j.ajhg.2009.02.001

DO - 10.1016/j.ajhg.2009.02.001

M3 - Article

C2 - 19268276

AN - SCOPUS:61849154183

SN - 0002-9297

VL - 84

SP - 367

EP - 379

JO - American journal of human genetics

JF - American journal of human genetics

IS - 3

ER -

Genome-wide Association Study of Smoking Initiation and Current Smoking

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