@article{67fc87d44ba3496eafe33599ef54fb49,
title = "Genome-wide association study of height and body mass index in Australian twin families",
abstract = "Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at ∼550,000 genotyped SNPs. We identified a single genomewide significant variant for height ( P value = 1.06 ×l 10 9) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height ( Pvalues < 1 × 10-6): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI ( Pvalues < 1 × 10-4): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.",
keywords = "BMI, Genetics, Height, Replication",
author = "Liu, {Jimmy Z.} and Medland, {Sarah E.} and Wright, {Margaret J.} and Henders, {Anjali K.} and Heath, {Andrew C.} and Madden, {Pamela A.F.} and Alexis Duncan and Montgomery, {Grant W.} and Martin, {Nicholas G.} and McRae, {Allan F.}",
note = "Funding Information: We thank the twins and their families for their participation. We also thank Dixie Statham, Ann Eldridge, Marlene Grace, Kerrie McAloney (sample collection); Megen Campbell, Lisa Bowdler, Steven Crooks (DNA processing); Scott Gordon, Gu Zhu, Manuel Ferreira, Daly Nyholt, Brian McEvoy (data cleaning); David Smyth, Harry Beeby, and Daniel Park (IT support). Funding was provided by the Australian National Health and Medical Research Council (241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498), the Australian Research Council (A7960034, A79906588, A79801419, DP0770096, DP0212016, DP0343921), the FP-5 GenomEUtwin Project (QLG2-CT-2002-01254), and the U.S. National Institutes of Health (NIH grants AA07535, AA10248, AA13320, AA13321, AA13326, AA14041, MH66206, DA12854). A portion of the genotyping on which this study was based (Illumina 370K scans on 4300 individuals) was carried out at the Center for Inherited Disease Research, Baltimore (CIDR), through an access award to our late colleague Dr Richard Todd (Psychiatry, Washington University School of Medicine, St Louis). A.F.M., S.E.M. and G.W.M. are supported by the National Health and Medical Research Council (NHMRC) Fellowship Scheme.",
year = "2010",
month = apr,
doi = "10.1375/twin.13.2.179",
language = "English",
volume = "13",
pages = "179--193",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
number = "2",
}