TY - JOUR
T1 - Genome-wide association study of Arabidopsis thaliana leaf microbial community
AU - Horton, Matthew W.
AU - Bodenhausen, Natacha
AU - Beilsmith, Kathleen
AU - Meng, Dazhe
AU - Muegge, Brian D.
AU - Subramanian, Sathish
AU - Vetter, M. Madlen
AU - Vilhjálmsson, Bjarni J.
AU - Nordborg, Magnus
AU - Gordon, Jeffrey I.
AU - Bergelson, Joy
N1 - Publisher Copyright:
© 2014 Macmillan Publishers Limited. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.
AB - Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84923360548&partnerID=8YFLogxK
U2 - 10.1038/ncomms6320
DO - 10.1038/ncomms6320
M3 - Article
C2 - 25382143
AN - SCOPUS:84923360548
SN - 2041-1723
VL - 5
JO - Nature communications
JF - Nature communications
M1 - 5320
ER -