@inproceedings{e6cc9d03221f45f8ba29d36c39896519,
title = "Genome-wide analysis of electrical phenotype using isodielectric separation",
abstract = "We present the first genome-wide analysis of electrical phenotype, focusing on the budding yeast Saccharomyces ce-revisiae. Using isodielectric separation (IDS), a microfluidic platform recently developed by our lab, we have screened the haploid yeast knock-out collection to identify genes whose deletion confers an increase or decrease in effective conductivity relative to wildtype cells. Pathway analysis and subsequent characterization of these deletion strains suggest biological processes and genetic pathways associated with distinct electrical phenotype. These results demonstrate the feasibility of IDS as a platform for genetic screens and establish a new class of phenotypic analysis - electrogenomic profiling.",
keywords = "Cell Separation, Dielectrophoresis, Electrical Properties, Genetic Screen",
author = "Vahey, {M. D.} and Svensson, {J. P.} and {Quiros Pesudo}, L. and Samson, {L. D.} and J. Voldman",
year = "2010",
language = "English",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "725--727",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
}