Genome screen for platelet monoamine oxidase (MAO) activity

Nancy L. Saccone; John P. Rice; Nan Rochberg; Alison Goate; Theodore Reich; Shantia Shears; William Wu; John I. Nurnberger; Tatiana Foroud; Howard J. Edenberg; Ting Kai Li

doi:10.1002/(SICI)1096-8628(19991015)88:5<517::AID-AJMG15>3.0.CO;2-B

Genome screen for platelet monoamine oxidase (MAO) activity

Nancy L. Saccone, John P. Rice, Nan Rochberg, Alison Goate, Theodore Reich, Shantia Shears, William Wu, John I. Nurnberger, Tatiana Foroud, Howard J. Edenberg, Ting Kai Li

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01:D6S1018 (p=0.0004), D2S1328 (p=0.008), and D2S408 (p=0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N=409) gave maximal lod scores of 2.0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.

Original language	English
Pages (from-to)	517-521
Number of pages	5
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	88
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19991015)88:5<517::AID-AJMG15>3.0.CO;2-B
State	Published - Oct 15 1999

Keywords

Linkage
MAO activity
Quantitative trait
Sib-pair analysis

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10.1002/(SICI)1096-8628(19991015)88:5<517::AID-AJMG15>3.0.CO;2-B

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Saccone, N. L., Rice, J. P., Rochberg, N., Goate, A., Reich, T., Shears, S., Wu, W., Nurnberger, J. I., Foroud, T., Edenberg, H. J., & Li, T. K. (1999). Genome screen for platelet monoamine oxidase (MAO) activity. American Journal of Medical Genetics - Neuropsychiatric Genetics, 88(5), 517-521. https://doi.org/10.1002/(SICI)1096-8628(19991015)88:5<517::AID-AJMG15>3.0.CO;2-B

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abstract = "To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01:D6S1018 (p=0.0004), D2S1328 (p=0.008), and D2S408 (p=0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N=409) gave maximal lod scores of 2.0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.",

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author = "Saccone, {Nancy L.} and Rice, {John P.} and Nan Rochberg and Alison Goate and Theodore Reich and Shantia Shears and William Wu and Nurnberger, {John I.} and Tatiana Foroud and Edenberg, {Howard J.} and Li, {Ting Kai}",

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AU - Saccone, Nancy L.

AU - Rice, John P.

AU - Rochberg, Nan

AU - Goate, Alison

AU - Reich, Theodore

AU - Shears, Shantia

AU - Wu, William

AU - Nurnberger, John I.

AU - Foroud, Tatiana

AU - Edenberg, Howard J.

AU - Li, Ting Kai

PY - 1999/10/15

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N2 - To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01:D6S1018 (p=0.0004), D2S1328 (p=0.008), and D2S408 (p=0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N=409) gave maximal lod scores of 2.0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.

AB - To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01:D6S1018 (p=0.0004), D2S1328 (p=0.008), and D2S408 (p=0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N=409) gave maximal lod scores of 2.0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.

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Genome screen for platelet monoamine oxidase (MAO) activity

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Keywords

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