TY - JOUR
T1 - Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol
T2 - The NHLBI Family Heart Study
AU - Peacock, James M.
AU - Arnett, Donna K.
AU - Atwood, Larry D.
AU - Myers, Richard H.
AU - Coon, Hilary
AU - Rich, Stephen S.
AU - Province, Michael A.
AU - Heiss, Gerardo
PY - 2001
Y1 - 2001
N2 - We conducted a genome-wide linkage scan for quantitative trait loci influencing total HDL-cholesterol (HDL-C) concentration in a sample of 1027 whites from 101 families participating in the NHLBI Family Heart Study. To maximize the relative contribution of genetic components of variance to the total variance of HDL-C, the HDL-C phenotype was adjusted for age, age2, body mass index, and Family Heart Study field center, and standardized HDL-C residuals were created separately for men and women. All analyses were completed by the variance components method, as implemented in the program GENEHUNTER using 383 anonymous markers typed at the NHLBI Mammalian Genotyping Service in Marshfield, Wis. Evidence for linkage of residual HDL-C was detected near marker D5S1470 at location 39.9 cM from the p-terminal of chromosome 5 (LOD=3.64). Suggestive linkage was detected near marker D13S1493 at location 27.5 cM on chromosome 13 (LOD=2.36). We conclude that at least 1 genomic region is likely to harbor a gene that influences interindividual variation in HDL cholesterol.
AB - We conducted a genome-wide linkage scan for quantitative trait loci influencing total HDL-cholesterol (HDL-C) concentration in a sample of 1027 whites from 101 families participating in the NHLBI Family Heart Study. To maximize the relative contribution of genetic components of variance to the total variance of HDL-C, the HDL-C phenotype was adjusted for age, age2, body mass index, and Family Heart Study field center, and standardized HDL-C residuals were created separately for men and women. All analyses were completed by the variance components method, as implemented in the program GENEHUNTER using 383 anonymous markers typed at the NHLBI Mammalian Genotyping Service in Marshfield, Wis. Evidence for linkage of residual HDL-C was detected near marker D5S1470 at location 39.9 cM from the p-terminal of chromosome 5 (LOD=3.64). Suggestive linkage was detected near marker D13S1493 at location 27.5 cM on chromosome 13 (LOD=2.36). We conclude that at least 1 genomic region is likely to harbor a gene that influences interindividual variation in HDL cholesterol.
KW - Anonymous marker linkage
KW - Genetic epidemiology
KW - Genome scan
KW - HDL cholesterol
KW - Quantitative trait loci
UR - http://www.scopus.com/inward/record.url?scp=0035569958&partnerID=8YFLogxK
U2 - 10.1161/hq1101.097804
DO - 10.1161/hq1101.097804
M3 - Article
C2 - 11701472
AN - SCOPUS:0035569958
SN - 1079-5642
VL - 21
SP - 1823
EP - 1828
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 11
ER -