Nicotine dependence is a heritable disorder predictive of difficulty with smoking cessation and carries most of the morbidity associated with smoking. Several independent studies have shown an allelic association between nicotine dependence and DNA variants in the region of the á5-á3-4 nicotinic receptor gene cluster on chromosome 15. Interestingly, the same region has been associatedwith lung cancer and chronic obstructive pulmonary disease. This highlights the importance of understanding the genetics of nicotine dependence in the context of smoking-related illness.

Translated title of the contributionGenetics of nicotine dependence
Original languageGerman
Pages (from-to)5-9
Number of pages5
JournalMedizinische Genetik
Issue number1
StatePublished - Feb 1 2010


  • Genome-wide association study
  • Human genetics
  • Lung neoplasms
  • Nicotine dependence
  • Receptors


Dive into the research topics of 'Genetics of nicotine dependence'. Together they form a unique fingerprint.

Cite this