Genetics of the extracellular matrix in aortic aneurysmal diseases

Research output: Contribution to journalReview article

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Abstract

Aortic aneurysms are morbid conditions that can lead to rupture or dissection and are categorized as thoracic (TAA) or abdominal aortic aneurysms (AAA) depending on their location. While AAA shares overlapping risk factors with atherosclerotic cardiovascular disease, TAA exhibits strong heritability. Human genetic studies in the past two decades have successfully identified numerous genes involved in both familial and sporadic forms of aortic aneurysm. In this review we will discuss the genetic basis of aortic aneurysm, focusing on the extracellular matrix and how insights from these studies have informed our understanding of human biology and disease pathogenesis.

Original languageEnglish
Pages (from-to)128-143
Number of pages16
JournalMatrix Biology
Volume71-72
DOIs
StatePublished - Oct 2018

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