Genetics of primary open-angle glaucoma

M. A. Kass, B. Becker

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Authors find that a substantial number of cases of primary open-angle glaucoma are familial and that relatives of primary open-angle glaucoma patients are at increased risk of developing glaucoma. Intraocular pressure, outflow facility, and cup/disc ratio all have multigenic, interrelated inheritance patterns. The response to topical corticosteroids appears to be inherited as an autosomal recessive and appears to be associated with primary open-angle glaucoma. This supports the hypothesis that there are substantial polygenic influences on primary open-angle glaucoma.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalSight Saving Review
Issue number1
StatePublished - 1978


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