Genetics of nicotine dependence and pharmacotherapy

Christina N. Lessov-Schlaggar, Michele L. Pergadia, Taline V. Khroyan, Gary E. Swan

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Nicotine dependence is substantially heritable. Several regions across the genome have been implicated in containing genes that confer liability to nicotine dependence and variation in individual genes has been associated with nicotine dependence. Smoking cessation measures are also heritable, and measured genetic variation is associated with nicotine dependence treatment efficacy. Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving. These challenges include refinement of the nicotine dependence phenotype, better understanding of the dynamic interplay between genes and environment in nicotine dependence etiology, application and development of molecular and statistical methodology that can adequately address vast amounts of data, and continuous translational cross-talk.

Original languageEnglish
Pages (from-to)178-195
Number of pages18
JournalBiochemical Pharmacology
Volume75
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Comorbidity
  • Environment
  • Genes
  • Pharmacogenetics
  • Phenotype refinement
  • Transdisciplinary

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