TY - JOUR
T1 - Genetics of nicotine dependence and pharmacotherapy
AU - Lessov-Schlaggar, Christina N.
AU - Pergadia, Michele L.
AU - Khroyan, Taline V.
AU - Swan, Gary E.
N1 - Funding Information:
This work was supported by internal funds from SRI International (CNLS, TVK), DA018019 (GES), and DA019951 (MLP). The authors have no conflicts of interest to report.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Nicotine dependence is substantially heritable. Several regions across the genome have been implicated in containing genes that confer liability to nicotine dependence and variation in individual genes has been associated with nicotine dependence. Smoking cessation measures are also heritable, and measured genetic variation is associated with nicotine dependence treatment efficacy. Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving. These challenges include refinement of the nicotine dependence phenotype, better understanding of the dynamic interplay between genes and environment in nicotine dependence etiology, application and development of molecular and statistical methodology that can adequately address vast amounts of data, and continuous translational cross-talk.
AB - Nicotine dependence is substantially heritable. Several regions across the genome have been implicated in containing genes that confer liability to nicotine dependence and variation in individual genes has been associated with nicotine dependence. Smoking cessation measures are also heritable, and measured genetic variation is associated with nicotine dependence treatment efficacy. Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving. These challenges include refinement of the nicotine dependence phenotype, better understanding of the dynamic interplay between genes and environment in nicotine dependence etiology, application and development of molecular and statistical methodology that can adequately address vast amounts of data, and continuous translational cross-talk.
KW - Comorbidity
KW - Environment
KW - Genes
KW - Pharmacogenetics
KW - Phenotype refinement
KW - Transdisciplinary
UR - http://www.scopus.com/inward/record.url?scp=36849039962&partnerID=8YFLogxK
U2 - 10.1016/j.bcp.2007.08.018
DO - 10.1016/j.bcp.2007.08.018
M3 - Article
C2 - 17888884
AN - SCOPUS:36849039962
SN - 0006-2952
VL - 75
SP - 178
EP - 195
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 1
ER -