TY - JOUR
T1 - Genetics of hypertension and cardiovascular disease and their interconnected pathways
T2 - Lessons from large studies
AU - Kraja, Aldi T.
AU - Hunt, Steven C.
AU - Rao, D. C.
AU - Dávila-Román, Victor G.
AU - Arnett, Donna K.
AU - Province, Michael A.
N1 - Funding Information:
Acknowledgment This work was supported in part by the National Institutes of Health (NIH) HyperGEN Study grant U01 HL54471 and in part by the NIH Genetic Determinants of the LVH Phenotype grant RO1 HL07178205A.
PY - 2011/2
Y1 - 2011/2
N2 - Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.
AB - Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.
KW - Blood pressure
KW - Cardiovascular disease
KW - GWAS
KW - Genome-wide association studies
KW - Hypertension
KW - Pathways
KW - SNPs
KW - Single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=79551574174&partnerID=8YFLogxK
U2 - 10.1007/s11906-010-0174-7
DO - 10.1007/s11906-010-0174-7
M3 - Article
C2 - 21128019
AN - SCOPUS:79551574174
SN - 1522-6417
VL - 13
SP - 46
EP - 54
JO - Current Hypertension Reports
JF - Current Hypertension Reports
IS - 1
ER -