Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies

Aldi T. Kraja, Steven C. Hunt, D. C. Rao, Victor G. Dávila-Román, Donna K. Arnett, Michael A. Province

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.

Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalCurrent Hypertension Reports
Volume13
Issue number1
DOIs
StatePublished - Feb 2011

Keywords

  • Blood pressure
  • Cardiovascular disease
  • GWAS
  • Genome-wide association studies
  • Hypertension
  • Pathways
  • SNPs
  • Single nucleotide polymorphisms

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