Genetics of Gastric Cancer

Matthew S. Strand, Albert Craig Lockhart, Ryan C. Fields

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Gastric cancer represents a major cause of cancer mortality worldwide despite a declining incidence. New molecular classification schemes developed from genomic and molecular analyses of gastric cancer have provided a framework for understanding this heterogenous disease, and early findings suggest these classifications will be relevant for designing and implementing new targeted therapies. The success of targeted therapy and immunotherapy in breast cancer and melanoma, respectively, has not been duplicated in gastric cancer, but trastuzumab and ramucirumab have demonstrated efficacy in select populations. New markers that predict therapeutic response are needed to improve patient selection for both targeted and immunotherapies.

Original languageEnglish
Pages (from-to)345-370
Number of pages26
JournalSurgical Clinics of North America
Issue number2
StatePublished - Apr 1 2017


  • Gastric adenocarcinoma
  • Gastric cancer
  • Genetics
  • Hereditary gastric cancer syndromes
  • Immunotherapy
  • Prophylactic gastrectomy
  • Targeted therapy


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