Genetics of bone loss in rheumatoid arthritis - Role of vitamin D receptor polymorphisms

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

RA is a systemic inflammatory arthritis that leads to local and systemic bone loss. Osteoporosis or the systemic bone loss associated with RA increases the risk for fragility fractures, which can affect quality of life dramatically in RA patients. Although traditional and RA-related risk factors have been defined and studied for osteoporosis associated with RA, genetic factors such as polymorphic variants in the traditional candidate genes for osteoporosis, such as the vitamin D receptor (VDR), type 1 collagen A1 (COLIA1) and oestrogen receptor-α (ESR1), have not been well elucidated in RA patients. This review summarizes the currently available literature on the association of VDR polymorphisms with local and systemic bone loss in RA. It also discusses potential targets for genetic research in this area, such as polymorphisms in genes, such as IL-6 (IL6) and TNF receptor type 2 (TNFRSF1B), which control the inflammatory response in RA and may influence bone loss in RA. Defining such genetic factors, in addition to traditional and RA-related risk factors for osteoporosis in RA, may facilitate early identification of patients at high risk for fractures who can then be targeted for treatment.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalRheumatology
Volume48
Issue number4
DOIs
StatePublished - Apr 2 2009

Keywords

  • Bone loss
  • Polymorphism
  • Rheumatoid arthritis
  • Vitamin D receptor

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