Genetics of age-related cataract

Alan Shiels; Patricia Espina Cabrera; J. Fielding Hejtmancik

doi:10.1016/B978-0-12-809324-5.01377-8

Genetics of age-related cataract

Alan Shiels, Patricia Espina Cabrera, J. Fielding Hejtmancik

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Age-related cataract is a leading cause of vision loss and the most common reason for eye surgery in the elderly. Epidemiological studies of affected siblings and twins indicate that genetic factors may account for as much as 50% of the risk for age-related cataract. Family-based linkage studies have identified a number of genetic susceptibility loci for age-related cataract, and case-control association studies have implicated a number of diverse candidate genes involved in: antioxidant metabolism, galactose metabolism, the heat-shock stress response, and the ephrin signaling pathway. Rigorous characterization of the underlying genetic causes may lead to nonsurgical treatments for age-related cataract.

Original language	English
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	207-210
Number of pages	4
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.01377-8
State	Published - Jan 1 2016

Keywords

Candidate genes
Cataract
Cortical
Ephrin-receptor
Galactokinase
Glutathione-s-transferase
Heat-shock transcription factor
Lens
Nuclear
Posterior sub-capsular
Senile

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10.1016/B978-0-12-809324-5.01377-8

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title = "Genetics of age-related cataract",

abstract = "Age-related cataract is a leading cause of vision loss and the most common reason for eye surgery in the elderly. Epidemiological studies of affected siblings and twins indicate that genetic factors may account for as much as 50% of the risk for age-related cataract. Family-based linkage studies have identified a number of genetic susceptibility loci for age-related cataract, and case-control association studies have implicated a number of diverse candidate genes involved in: antioxidant metabolism, galactose metabolism, the heat-shock stress response, and the ephrin signaling pathway. Rigorous characterization of the underlying genetic causes may lead to nonsurgical treatments for age-related cataract.",

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AU - Shiels, Alan

AU - Cabrera, Patricia Espina

AU - Hejtmancik, J. Fielding

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N2 - Age-related cataract is a leading cause of vision loss and the most common reason for eye surgery in the elderly. Epidemiological studies of affected siblings and twins indicate that genetic factors may account for as much as 50% of the risk for age-related cataract. Family-based linkage studies have identified a number of genetic susceptibility loci for age-related cataract, and case-control association studies have implicated a number of diverse candidate genes involved in: antioxidant metabolism, galactose metabolism, the heat-shock stress response, and the ephrin signaling pathway. Rigorous characterization of the underlying genetic causes may lead to nonsurgical treatments for age-related cataract.

AB - Age-related cataract is a leading cause of vision loss and the most common reason for eye surgery in the elderly. Epidemiological studies of affected siblings and twins indicate that genetic factors may account for as much as 50% of the risk for age-related cataract. Family-based linkage studies have identified a number of genetic susceptibility loci for age-related cataract, and case-control association studies have implicated a number of diverse candidate genes involved in: antioxidant metabolism, galactose metabolism, the heat-shock stress response, and the ephrin signaling pathway. Rigorous characterization of the underlying genetic causes may lead to nonsurgical treatments for age-related cataract.

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KW - Cortical

KW - Ephrin-receptor

KW - Galactokinase

KW - Glutathione-s-transferase

KW - Heat-shock transcription factor

KW - Lens

KW - Nuclear

KW - Posterior sub-capsular

KW - Senile

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M3 - Chapter

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BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

PB - Elsevier Science Ltd.

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Genetics of age-related cataract

Abstract

Keywords

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