Genetics of age-related cataract

A. Shiels, J. F. Hejtmancik

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Age-related cataract is a leading cause of vision loss and the most common reason for eye surgery in the elderly. Epidemiological studies of affected siblings and twins indicate that genetic factors may account for as much as 50% of the risk for age-related cataract. Family-based linkage studies have identified a number of genetic susceptibility loci for age-related cataract, and case-control association studies have implicated a number of diverse candidate genes involved in: antioxidant metabolism, galactose metabolism, the heat-shock stress response, and the ephrin signaling pathway. Rigorous characterization of the underlying genetic causes may lead to nonsurgical treatments for age-related cataract.

Original languageEnglish
Title of host publicationEncyclopedia of the Eye, Four-Volume Set
Number of pages4
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
StatePublished - Jan 1 2010


  • Candidate genes
  • Cataract
  • Cortical
  • Ephrin-receptor
  • Galactokinase
  • Glutathione-S-transferase
  • Heat-shock transcription factor
  • Lens
  • Nuclear
  • Posterior sub-capsular
  • Senile


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