Genetics, Brain, and Personality: Searching for Intermediate Phenotypes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Recent theoretical and methodological advances in human genetics and neuroscience offer novel opportunities for understanding biological bases of personality. Building a unifying, biologically based theory of personality will require the elucidation of complex links between genes, brain, and personality traits. Accordingly, in this chapter we review, summarize, and critically evaluate three related lines of research: genetic research on personality, investigation of the relationships between individual variability in the brain and personality traits, and genetic studies of brain structure and function. We also demonstrate how these research directions can be integrated using genetically informative designs in order to determine how genetic influences on personality are mediated by variability in brain structure and function. In conclusion, we identify critical issues that should be addressed in future studies.

Original languageEnglish
Title of host publicationNeuroimaging Personality, Social Cognition, and Character
PublisherElsevier Inc.
Number of pages20
ISBN (Print)9780128009352
StatePublished - 2016


  • Brain
  • Endophenotype
  • Genetics
  • Personality
  • Temperament


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