@article{6d5127a09e5342c29b3e781ee1f316c7,
title = "Genetics and population analysis: Estimating and testing high-dimensional mediation effects in epigenetic studies",
abstract = "Motivation: High-dimensional DNA methylation markers may mediate pathways linking environmental exposures with health outcomes. However, there is a lack of analytical methods to identify significant mediators for high-dimensional mediation analysis. Results: Based on sure independent screening and minimax concave penalty techniques, we use a joint significance test for mediation effect. We demonstrate its practical performance using Monte Carlo simulation studies and apply this method to investigate the extent to which DNA methylation markers mediate the causal pathway from smoking to reduced lung function in the Normative Aging Study. We identify 2 CpGs with significant mediation effects.",
author = "Haixiang Zhang and Yinan Zheng and Zhou Zhang and Tao Gao and Brian Joyce and Grace Yoon and Wei Zhang and Joel Schwartz and Allan Just and Elena Colicino and Pantel Vokonas and Lihui Zhao and Jinchi Lv and Andrea Baccarelli and Lifang Hou and Lei Liu",
note = "Funding Information: This work was supported by AHA 14SFRN20480260, 12GRNT12070254 and National Institute of Environmental Health Sciences (R01ES021357, R01ES021733 and R01ES015172), National Natural Science Foundation of China (11301212, 11401146), and China Postdoctoral Science Foundation (2014M550861). The VA Normative Aging Study is supported by the Cooperative Studies Program/Epidemiology Research and Information Center of the US Department of Veterans Affairs. Publisher Copyright: {\textcopyright} The Author 2016. Published by Oxford University Press. All rights reserved.",
year = "2016",
month = oct,
day = "15",
doi = "10.1093/bioinformatics/btw351",
language = "English",
volume = "32",
pages = "3150--3154",
journal = "Bioinformatics",
issn = "1367-4803",
number = "20",
}