Genetics and Pathogenesis of Inflammatory Bowel Disease

Ta Chiang Liu, Thaddeus S. Stappenbeck

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

We are currently in an exciting time when our understanding of genetic underpinnings of inflammatory bowel disease (IBD) has undergone a revolution, based in large part on novel genotyping and sequencing technologies. With >160 susceptible loci identified for IBD, the goal is now to understand at a fundamental level the function of these susceptibility alleles. Determining the clinical relevance of how these susceptible genes shape the development of IBD is also a high priority. The main challenge is to understand how the environment and microbiome play a role in triggering disease in genetically susceptible individuals, as the interactions may be complex. To advance the field, novel in vitro and mouse models that are designed to interrogate complex genetics and functionally test hypotheses are needed. Ultimately, the goal of genetics studies will be to translate genetics to patients with IBD and improve their care.

Original languageEnglish
Pages (from-to)127-148
Number of pages22
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume11
DOIs
StatePublished - May 23 2016

Keywords

  • Causative variants
  • Crohn's disease
  • Genome-wide association study
  • Ulcerative colitis

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