Possible genetic and environmental determinants of multifocal nodular renal blastema (NRB) were investigated by interviewing parents of affected children and matched controls. We found significant associations with frequent use of coffee or tea and exposure to synthetic progestins during index pregnancies. Associated congenital anomalies, particularly hemihypertrophy, were unusually frequent in patients with Wilms’ tumor and NRB. NRB alone may be specifically linked to isolated congenital heart disease in infants. Sibs of index cases were similar to controls in number and type of anomalies and rarity of cancer to date, but the families of index children have excess cancer prevalence compared to controls. The data suggest that environmental factors may be important co-determinants of Wilms’ tumor. A genetic determinant, if it exists, may have a general, rather than tumor-specific, effect.
|Number of pages||7|
|Journal||American Journal of Pediatric Hematology/Oncology|
|State||Published - 1980|