Genetically linked C-typed lectin-related ligands for the NKRP1 family of natural killer cell receptors

Koho Iizuka; Olga V. Naidenko; Beatrice F.M. Plougastel; Daved H. Fremont; Wayne M. Yokoyama

doi:10.1038/ni954

Genetically linked C-typed lectin-related ligands for the NKRP1 family of natural killer cell receptors

Koho Iizuka, Olga V. Naidenko, Beatrice F.M. Plougastel, Daved H. Fremont, Wayne M. Yokoyama

Research output: Contribution to journal › Article › peer-review

242 Scopus citations

Abstract

The natural killer (NK) gene complex (NKC) encodes orphan lectin-like NK cell receptors that may explain uncharacterized NK cell specificities. Unlike other NKC-encoded receptors that recognize molecules with major histocompatibility complex (MHC) class I folds, here we show that mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 (official gene name, Klrb1) and Clr are intertwined in a genetically conserved NKC region showing recombination suppression, reminiscent of plant self-incompatibility loci. Thus, these findings broaden the 'missing-self' hypothesis from solely involving MHC class I to including related NK cell receptors for lectin-like ligands, and reflect genetic strategies for biological self-recognition processes in other species.

Original language	English
Pages (from-to)	801-807
Number of pages	7
Journal	Nature immunology
Volume	4
Issue number	8
DOIs	https://doi.org/10.1038/ni954
State	Published - Aug 1 2003

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title = "Genetically linked C-typed lectin-related ligands for the NKRP1 family of natural killer cell receptors",

abstract = "The natural killer (NK) gene complex (NKC) encodes orphan lectin-like NK cell receptors that may explain uncharacterized NK cell specificities. Unlike other NKC-encoded receptors that recognize molecules with major histocompatibility complex (MHC) class I folds, here we show that mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 (official gene name, Klrb1) and Clr are intertwined in a genetically conserved NKC region showing recombination suppression, reminiscent of plant self-incompatibility loci. Thus, these findings broaden the 'missing-self' hypothesis from solely involving MHC class I to including related NK cell receptors for lectin-like ligands, and reflect genetic strategies for biological self-recognition processes in other species.",

author = "Koho Iizuka and Naidenko, {Olga V.} and Plougastel, {Beatrice F.M.} and Fremont, {Daved H.} and Yokoyama, {Wayne M.}",

note = "Funding Information: We thank J. Laurent, E. Blattenberger and L. Yang for technical support, J. Nasrallah (Cornell University) for discussions, and E. Unanue, M. Colonna, T. Hansen and A. French for comments on the manuscript. Work in the Yokoyama laboratory is supported by the Howard Hughes Medical Institute, the Barnes-Jewish Hospital Foundation and grants from the National Institutes of Health. The Burroughs-Wellcome Fund, Kilo Foundation and National Institutes of Health support work in the Fremont laboratory. O.V.N. is supported by a Cancer Research Institute postdoctoral fellowship.",

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AU - Naidenko, Olga V.

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AU - Fremont, Daved H.

AU - Yokoyama, Wayne M.

N1 - Funding Information: We thank J. Laurent, E. Blattenberger and L. Yang for technical support, J. Nasrallah (Cornell University) for discussions, and E. Unanue, M. Colonna, T. Hansen and A. French for comments on the manuscript. Work in the Yokoyama laboratory is supported by the Howard Hughes Medical Institute, the Barnes-Jewish Hospital Foundation and grants from the National Institutes of Health. The Burroughs-Wellcome Fund, Kilo Foundation and National Institutes of Health support work in the Fremont laboratory. O.V.N. is supported by a Cancer Research Institute postdoctoral fellowship.

PY - 2003/8/1

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N2 - The natural killer (NK) gene complex (NKC) encodes orphan lectin-like NK cell receptors that may explain uncharacterized NK cell specificities. Unlike other NKC-encoded receptors that recognize molecules with major histocompatibility complex (MHC) class I folds, here we show that mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 (official gene name, Klrb1) and Clr are intertwined in a genetically conserved NKC region showing recombination suppression, reminiscent of plant self-incompatibility loci. Thus, these findings broaden the 'missing-self' hypothesis from solely involving MHC class I to including related NK cell receptors for lectin-like ligands, and reflect genetic strategies for biological self-recognition processes in other species.

AB - The natural killer (NK) gene complex (NKC) encodes orphan lectin-like NK cell receptors that may explain uncharacterized NK cell specificities. Unlike other NKC-encoded receptors that recognize molecules with major histocompatibility complex (MHC) class I folds, here we show that mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 (official gene name, Klrb1) and Clr are intertwined in a genetically conserved NKC region showing recombination suppression, reminiscent of plant self-incompatibility loci. Thus, these findings broaden the 'missing-self' hypothesis from solely involving MHC class I to including related NK cell receptors for lectin-like ligands, and reflect genetic strategies for biological self-recognition processes in other species.

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Genetically linked C-typed lectin-related ligands for the NKRP1 family of natural killer cell receptors

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