TY - JOUR
T1 - Genetic Vulnerability and Susceptibility to Substance Dependence
AU - Bierut, Laura Jean
N1 - Funding Information:
This work was supported by grants from the National Institute on Drug Abuse (K02 DA021237, R01 DA019963), the National Cancer Institute (P01 CA089392), and the National Institute on Alcohol Abuse and Alcoholism (U10 AA008401). The assistance of Sherri Fisher was key in the preparation of this manuscript. Dr. Bierut is listed as an inventor on a patent, “Markers of Addiction,” covering the use of certain SNPs in diagnosing, prognosing, and treating addiction. Dr. Bierut served as a consultant to Pfizer in 2008.
PY - 2011/2/24
Y1 - 2011/2/24
N2 - The development of substance dependence requires the initiation of substance use and the conversion from experimental use to established use before development of dependence. Numerous large twin studies have indicated a significant genetic contribution to this process. Genetic studies to date have been most successful at identifying genetic factors that influence the transition from regular use to dependence. The availability of large cohort samples for nicotine and alcohol dependence has resulted in significant progress being made in understanding at least some of the genetic contributions to these addictions. Fewer studies have replicated specific genetic contributions to illicit drug use, though it is clear that there is a strong genetic component involved here as well. Substance dependence can be thought of as a pharmacogenetic illness, and most likely hundreds and more probably thousands of genetic variants will be required to fully explain the genetic input to this disease.
AB - The development of substance dependence requires the initiation of substance use and the conversion from experimental use to established use before development of dependence. Numerous large twin studies have indicated a significant genetic contribution to this process. Genetic studies to date have been most successful at identifying genetic factors that influence the transition from regular use to dependence. The availability of large cohort samples for nicotine and alcohol dependence has resulted in significant progress being made in understanding at least some of the genetic contributions to these addictions. Fewer studies have replicated specific genetic contributions to illicit drug use, though it is clear that there is a strong genetic component involved here as well. Substance dependence can be thought of as a pharmacogenetic illness, and most likely hundreds and more probably thousands of genetic variants will be required to fully explain the genetic input to this disease.
UR - http://www.scopus.com/inward/record.url?scp=79951694140&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2011.02.015
DO - 10.1016/j.neuron.2011.02.015
M3 - Review article
C2 - 21338875
AN - SCOPUS:79951694140
SN - 0896-6273
VL - 69
SP - 618
EP - 627
JO - Neuron
JF - Neuron
IS - 4
ER -