Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer

Peter Kraft; Paul Pharoah; Stephen J. Chanock; Demetrius Albanes; Laurence N. Kolone; Richard B. Hayes; David Altshuler; Gerald Andriole; Christine Berg; Heiner Boeing; Noel P. Burtt; Bas Bueno-de-Mesquita; Eugenia E. Calle; Howard Cann; Federico Canzian; Yen Ching Chen; David E. Crawford; Alison M. Dunning; Heather S. Feigelson; Matthew L. Freedman; John M. Gaziano; Ed Giovannucci; Carlos Alberto Gonzalez; Christopher A. Haiman; Goran Hallmans; Brian E. Henderson; Joel N. Hirschhorn; David J. Hunter; Rudolf Kaaks; Timothy Key; Loic Le Marchand; Ma Jing; Kim Overvad; Domenico Palli; Malcolm C. Pike; Elio Riboli; Carmen Rodriguez; Wendy V. Setiawan; Meir J. Stampfer; Daniel O. Stram; Gilles Thomas; Michael J. Thun; Ruth Travis; Antonia Trichopoulou; Jarmo Virtamo; Sholom Wacholder

doi:10.1371/journal.pgen.0010068

Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer

Peter Kraft, Paul Pharoah, Stephen J. Chanock, Demetrius Albanes, Laurence N. Kolone, Richard B. Hayes, David Altshuler, Gerald Andriole, Christine Berg, Heiner Boeing, Noel P. Burtt, Bas Bueno-de-Mesquita, Eugenia E. Calle, Howard Cann, Federico Canzian, Yen Ching Chen, David E. Crawford, Alison M. Dunning, Heather S. Feigelson, Matthew L. FreedmanJohn M. Gaziano, Ed Giovannucci, Carlos Alberto Gonzalez, Christopher A. Haiman, Goran Hallmans, Brian E. Henderson, Joel N. Hirschhorn, David J. Hunter, Rudolf Kaaks, Timothy Key, Loic Le Marchand, Ma Jing, Kim Overvad, Domenico Palli, Malcolm C. Pike, Elio Riboli, Carmen Rodriguez, Wendy V. Setiawan, Meir J. Stampfer, Daniel O. Stram, Gilles Thomas, Michael J. Thun, Ruth Travis, Antonia Trichopoulou, Jarmo Virtamo, Sholom Wacholder

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Abstract

Steroid hormones are believed to play am important raie In prostate carcirtogenesis, but epidemioiogica! evidence unking prostate cancer and steroid hormone genes has been meoncSusive, in part dye to smai! sample sizes or incomplete characterization of genetic variation! at the locus of interest. Here we report ors the reswits of a comprehensive study of the association between HSD1781 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a iarge coHaborative study. HSD17B1 encodes 17β-hydroxysteraid dehydrogenase 1, art enzyme that converts dahydroepiandrosterane to the testosterone precursor Ä§-androsteron6-3β,17β-d!Gl and converts estrarse to estradioa. The Breast and Prostate Cancer Cohort Consortium researchers systematically characterized variation in HS017S? by targeted resequeneing and dense genotyping; seiected hapiotype-tagging single nwcSeotide polymorphisms (htSMPsj that effiderstiy predict common variants in ILS, and European whites. Latinos, Japanese Americans, and Mative Hawaiians; and genotyped these htSNPs in 8,290 prostate cancer eases and 9,367 stydy-, age-, and ethnicity-matched controls. We found no evidence that HSD17B1 htSMPs {inciudirsg the nonsyrsonymows coding SNP S312G) or htSMP hapfotypes were associated with risk of prostate cancer or tumor stage in the pooled myStiethnlc sample or In U.S. and European whites. Analyses stratified by age, body mass index, and family history of disease found no sybgroyp-specific associations between these HSD17B1 htSMPs and prostate cancer. We foyrsd significant evidence of heterogeneity In associations between HSD17B1 hapiotypes and prostate cancer across ethnicity: one haplotype had a significant {p < 0.002} inverse association with risk of prostate cancer in Latinos and Japanese Americans but showed no evidence of association in African Americans, Mative Hawaiians, or whites. However, the smaiier numbers of Latinos and Japanese Americans in this study makes these subgroup analyses iess reliable. These results suggest that the germiine variants in HSD17B1 characterized by these htSMPs do not substantially influence the risk of prostate cancer in U.S. and European whites. Copyright:

Original language	English
Pages (from-to)	603-613
Number of pages	11
Journal	PLoS genetics
Volume	1
Issue number	5
DOIs	https://doi.org/10.1371/journal.pgen.0010068
State	Published - 2005

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10.1371/journal.pgen.0010068

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Kraft, P., Pharoah, P., Chanock, S. J., Albanes, D., Kolone, L. N., Hayes, R. B., Altshuler, D., Andriole, G., Berg, C., Boeing, H., Burtt, N. P., Bueno-de-Mesquita, B., Calle, E. E., Cann, H., Canzian, F., Chen, Y. C., Crawford, D. E., Dunning, A. M., Feigelson, H. S., ... Wacholder, S. (2005). Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer. PLoS genetics, 1(5), 603-613. https://doi.org/10.1371/journal.pgen.0010068

@article{d5b27b818e9e4eaaa56c4f543e2dd134,

title = "Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer",

abstract = "Steroid hormones are believed to play am important raie In prostate carcirtogenesis, but epidemioiogica! evidence unking prostate cancer and steroid hormone genes has been meoncSusive, in part dye to smai! sample sizes or incomplete characterization of genetic variation! at the locus of interest. Here we report ors the reswits of a comprehensive study of the association between HSD1781 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a iarge coHaborative study. HSD17B1 encodes 17β-hydroxysteraid dehydrogenase 1, art enzyme that converts dahydroepiandrosterane to the testosterone precursor {\"A}§-androsteron6-3β,17β-d!Gl and converts estrarse to estradioa. The Breast and Prostate Cancer Cohort Consortium researchers systematically characterized variation in HS017S? by targeted resequeneing and dense genotyping; seiected hapiotype-tagging single nwcSeotide polymorphisms (htSMPsj that effiderstiy predict common variants in ILS, and European whites. Latinos, Japanese Americans, and Mative Hawaiians; and genotyped these htSNPs in 8,290 prostate cancer eases and 9,367 stydy-, age-, and ethnicity-matched controls. We found no evidence that HSD17B1 htSMPs {inciudirsg the nonsyrsonymows coding SNP S312G) or htSMP hapfotypes were associated with risk of prostate cancer or tumor stage in the pooled myStiethnlc sample or In U.S. and European whites. Analyses stratified by age, body mass index, and family history of disease found no sybgroyp-specific associations between these HSD17B1 htSMPs and prostate cancer. We foyrsd significant evidence of heterogeneity In associations between HSD17B1 hapiotypes and prostate cancer across ethnicity: one haplotype had a significant {p < 0.002} inverse association with risk of prostate cancer in Latinos and Japanese Americans but showed no evidence of association in African Americans, Mative Hawaiians, or whites. However, the smaiier numbers of Latinos and Japanese Americans in this study makes these subgroup analyses iess reliable. These results suggest that the germiine variants in HSD17B1 characterized by these htSMPs do not substantially influence the risk of prostate cancer in U.S. and European whites. Copyright:",

author = "Peter Kraft and Paul Pharoah and Chanock, {Stephen J.} and Demetrius Albanes and Kolone, {Laurence N.} and Hayes, {Richard B.} and David Altshuler and Gerald Andriole and Christine Berg and Heiner Boeing and Burtt, {Noel P.} and Bas Bueno-de-Mesquita and Calle, {Eugenia E.} and Howard Cann and Federico Canzian and Chen, {Yen Ching} and Crawford, {David E.} and Dunning, {Alison M.} and Feigelson, {Heather S.} and Freedman, {Matthew L.} and Gaziano, {John M.} and Ed Giovannucci and Gonzalez, {Carlos Alberto} and Haiman, {Christopher A.} and Goran Hallmans and Henderson, {Brian E.} and Hirschhorn, {Joel N.} and Hunter, {David J.} and Rudolf Kaaks and Timothy Key and Marchand, {Loic Le} and Ma Jing and Kim Overvad and Domenico Palli and Pike, {Malcolm C.} and Elio Riboli and Carmen Rodriguez and Setiawan, {Wendy V.} and Stampfer, {Meir J.} and Stram, {Daniel O.} and Gilles Thomas and Thun, {Michael J.} and Ruth Travis and Antonia Trichopoulou and Jarmo Virtamo and Sholom Wacholder",

year = "2005",

doi = "10.1371/journal.pgen.0010068",

language = "English",

volume = "1",

pages = "603--613",

journal = "PLoS genetics",

issn = "1553-7390",

number = "5",

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Kraft, P, Pharoah, P, Chanock, SJ, Albanes, D, Kolone, LN, Hayes, RB, Altshuler, D, Andriole, G, Berg, C, Boeing, H, Burtt, NP, Bueno-de-Mesquita, B, Calle, EE, Cann, H, Canzian, F, Chen, YC, Crawford, DE, Dunning, AM, Feigelson, HS, Freedman, ML, Gaziano, JM, Giovannucci, E, Gonzalez, CA, Haiman, CA, Hallmans, G, Henderson, BE, Hirschhorn, JN, Hunter, DJ, Kaaks, R, Key, T, Marchand, LL, Jing, M, Overvad, K, Palli, D, Pike, MC, Riboli, E, Rodriguez, C, Setiawan, WV, Stampfer, MJ, Stram, DO, Thomas, G, Thun, MJ, Travis, R, Trichopoulou, A, Virtamo, J & Wacholder, S 2005, 'Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer', PLoS genetics, vol. 1, no. 5, pp. 603-613. https://doi.org/10.1371/journal.pgen.0010068

TY - JOUR

T1 - Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer

AU - Kraft, Peter

AU - Pharoah, Paul

AU - Chanock, Stephen J.

AU - Albanes, Demetrius

AU - Kolone, Laurence N.

AU - Hayes, Richard B.

AU - Altshuler, David

AU - Andriole, Gerald

AU - Berg, Christine

AU - Boeing, Heiner

AU - Burtt, Noel P.

AU - Bueno-de-Mesquita, Bas

AU - Calle, Eugenia E.

AU - Cann, Howard

AU - Canzian, Federico

AU - Chen, Yen Ching

AU - Crawford, David E.

AU - Dunning, Alison M.

AU - Feigelson, Heather S.

AU - Freedman, Matthew L.

AU - Gaziano, John M.

AU - Giovannucci, Ed

AU - Gonzalez, Carlos Alberto

AU - Haiman, Christopher A.

AU - Hallmans, Goran

AU - Henderson, Brian E.

AU - Hirschhorn, Joel N.

AU - Hunter, David J.

AU - Kaaks, Rudolf

AU - Key, Timothy

AU - Marchand, Loic Le

AU - Jing, Ma

AU - Overvad, Kim

AU - Palli, Domenico

AU - Pike, Malcolm C.

AU - Riboli, Elio

AU - Rodriguez, Carmen

AU - Setiawan, Wendy V.

AU - Stampfer, Meir J.

AU - Stram, Daniel O.

AU - Thomas, Gilles

AU - Thun, Michael J.

AU - Travis, Ruth

AU - Trichopoulou, Antonia

AU - Virtamo, Jarmo

AU - Wacholder, Sholom

PY - 2005

Y1 - 2005

N2 - Steroid hormones are believed to play am important raie In prostate carcirtogenesis, but epidemioiogica! evidence unking prostate cancer and steroid hormone genes has been meoncSusive, in part dye to smai! sample sizes or incomplete characterization of genetic variation! at the locus of interest. Here we report ors the reswits of a comprehensive study of the association between HSD1781 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a iarge coHaborative study. HSD17B1 encodes 17β-hydroxysteraid dehydrogenase 1, art enzyme that converts dahydroepiandrosterane to the testosterone precursor Ä§-androsteron6-3β,17β-d!Gl and converts estrarse to estradioa. The Breast and Prostate Cancer Cohort Consortium researchers systematically characterized variation in HS017S? by targeted resequeneing and dense genotyping; seiected hapiotype-tagging single nwcSeotide polymorphisms (htSMPsj that effiderstiy predict common variants in ILS, and European whites. Latinos, Japanese Americans, and Mative Hawaiians; and genotyped these htSNPs in 8,290 prostate cancer eases and 9,367 stydy-, age-, and ethnicity-matched controls. We found no evidence that HSD17B1 htSMPs {inciudirsg the nonsyrsonymows coding SNP S312G) or htSMP hapfotypes were associated with risk of prostate cancer or tumor stage in the pooled myStiethnlc sample or In U.S. and European whites. Analyses stratified by age, body mass index, and family history of disease found no sybgroyp-specific associations between these HSD17B1 htSMPs and prostate cancer. We foyrsd significant evidence of heterogeneity In associations between HSD17B1 hapiotypes and prostate cancer across ethnicity: one haplotype had a significant {p < 0.002} inverse association with risk of prostate cancer in Latinos and Japanese Americans but showed no evidence of association in African Americans, Mative Hawaiians, or whites. However, the smaiier numbers of Latinos and Japanese Americans in this study makes these subgroup analyses iess reliable. These results suggest that the germiine variants in HSD17B1 characterized by these htSMPs do not substantially influence the risk of prostate cancer in U.S. and European whites. Copyright:

AB - Steroid hormones are believed to play am important raie In prostate carcirtogenesis, but epidemioiogica! evidence unking prostate cancer and steroid hormone genes has been meoncSusive, in part dye to smai! sample sizes or incomplete characterization of genetic variation! at the locus of interest. Here we report ors the reswits of a comprehensive study of the association between HSD1781 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a iarge coHaborative study. HSD17B1 encodes 17β-hydroxysteraid dehydrogenase 1, art enzyme that converts dahydroepiandrosterane to the testosterone precursor Ä§-androsteron6-3β,17β-d!Gl and converts estrarse to estradioa. The Breast and Prostate Cancer Cohort Consortium researchers systematically characterized variation in HS017S? by targeted resequeneing and dense genotyping; seiected hapiotype-tagging single nwcSeotide polymorphisms (htSMPsj that effiderstiy predict common variants in ILS, and European whites. Latinos, Japanese Americans, and Mative Hawaiians; and genotyped these htSNPs in 8,290 prostate cancer eases and 9,367 stydy-, age-, and ethnicity-matched controls. We found no evidence that HSD17B1 htSMPs {inciudirsg the nonsyrsonymows coding SNP S312G) or htSMP hapfotypes were associated with risk of prostate cancer or tumor stage in the pooled myStiethnlc sample or In U.S. and European whites. Analyses stratified by age, body mass index, and family history of disease found no sybgroyp-specific associations between these HSD17B1 htSMPs and prostate cancer. We foyrsd significant evidence of heterogeneity In associations between HSD17B1 hapiotypes and prostate cancer across ethnicity: one haplotype had a significant {p < 0.002} inverse association with risk of prostate cancer in Latinos and Japanese Americans but showed no evidence of association in African Americans, Mative Hawaiians, or whites. However, the smaiier numbers of Latinos and Japanese Americans in this study makes these subgroup analyses iess reliable. These results suggest that the germiine variants in HSD17B1 characterized by these htSMPs do not substantially influence the risk of prostate cancer in U.S. and European whites. Copyright:

UR - http://www.scopus.com/inward/record.url?scp=55449108364&partnerID=8YFLogxK

U2 - 10.1371/journal.pgen.0010068

DO - 10.1371/journal.pgen.0010068

M3 - Article

C2 - 16311626

AN - SCOPUS:55449108364

SN - 1553-7390

VL - 1

SP - 603

EP - 613

JO - PLoS genetics

JF - PLoS genetics

IS - 5

ER -

Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer

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