Genetic variants in the renin-angiotensin system and blood pressure reactions to the cold pressor test

Laiyuan Wang, Liping Hou, Hongfan Li, Jing Chen, Tanika N. Kelly, Cashell E. Jaquish, Dabeeru C. Rao, James E. Hixson, Dongsheng Hu, Chung Shiuan Chen, Charles Gu, Shufeng Chen, Xiangfeng Lu, Paul K. Whelton, Jiang He, Fanghong Lu, Jianfeng Huang, De Pei Liu, Dongfeng Gu

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Objectives The purpose of this study was to examine the association between genetic variants in the renin- angiotensin system and blood pressure (BP) responses to the cold pressor test (CPT). Methods The CPT was conducted among 1998 Han Chinese participants. BP measurements were obtained before and after the CPT using a standard sphygmomanometer according to a standard protocol. The association between SNP genotypes and BP responses to the CPT was assessed using a mixed linear model. Results Of 68 SNPs genotyped in six renin-angiotensin system genes, two were strongly associated with DBP responses to CPT (P<- 0.001; false discovery rate q value < 0.05): Rs2006765 and rs943580 in the angiotensinogen (AGT) gene. Compared to C allele carriers of rs2006765, the TT homozygotes had a significantly decreased DBP response to the CPT. For participants with the TT genotype, percentage DBP responses were 5.68% (4.25-7.10%), compared to corresponding responses of 9.17% (8.66- 9.68%) among participants with the CCRCT genotype. In addition, SNP rs4681443 of the angiotensin type 1 receptor (AGTR1) gene was significantly associated with percentage SBP responses to CPT (P<- 0.001; q-value <0.05). Conclusion Briefly, our study identified variants in the AGT and AGTR1 genes that may influence BP responses to CPT in the Han Chinese population. These results show that genetic variants in the renin-angiotensin system play an important role in BP responses to CPT and, therefore, in predicting future hypertension.

Original languageEnglish
Pages (from-to)2422-2428
Number of pages7
JournalJournal of Hypertension
Issue number12
StatePublished - Dec 2010


  • Blood pressure
  • Cold pressor test
  • Genetics
  • Polymorphism
  • Renin-angiotensin system


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