Traumatic and sports injuries are associated with the development of post-traumatic osteoarthritis (PTOA). The variation in the healing response of these injuries present a great challenge for clinicians to envisage the healing outcomes. Several factors are known to influence the variation in the healing sequelae such as age, sex, extent and magnitude of injury, and genetics. In this chapter, we cite mouse and human studies that favor the participation of genetics as a major factor in the healing response of injured tissues as well as in the susceptibility to PTOA. First, we present evidence from mouse studies that show genetic variation in the healing of ear-wound and articular cartilage and from those that show the genetic variability in experimental PTOA. Second, we summarize the studies in human population that use genome-wide association scans to detect the gene variants, which are potentially thought to drive the susceptibility to OA. Third, we discuss variation in the healing of human anterior cruciate ligament injuries that may be genetically modulated. Finally, we provide a few examples of genetic variation in the response to injury in non-musculoskeletal system.

Original languageEnglish
Title of host publicationPost-Traumatic Arthritis
Subtitle of host publicationPathogenesis, Diagnosis and Management
PublisherSpringer US
Number of pages16
ISBN (Electronic)9781489976062
ISBN (Print)9781489976055
StatePublished - Jan 1 2015


  • Anterior cruciate ligament
  • Articular cartilage
  • Genetic variation
  • Genome-wide association scans
  • Post-traumatic osteoarthritis
  • Tissue repair
  • Trauma


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