Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development

Mehmet L. Güler, James D. Gorham, Chyi Song Hsieh, Aaron J. Mackey, Robert G. Steen, William F. Dietrich, Kenneth M. Murphy

Research output: Contribution to journalArticlepeer-review

331 Scopus citations


The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naïve T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response.

Original languageEnglish
Pages (from-to)984-987
Number of pages4
Issue number5251
StatePublished - Feb 16 1996

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