Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice

Tiffany Hensley-McBain; Miranda E. Orr

doi:10.1016/j.neuron.2024.10.025

Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice

Tiffany Hensley-McBain
, Miranda E. Orr

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.

Original language	English
Pages (from-to)	3811-3813
Number of pages	3
Journal	Neuron
Volume	112
Issue number	23
DOIs	https://doi.org/10.1016/j.neuron.2024.10.025
State	Published - Dec 4 2024

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10.1016/j.neuron.2024.10.025

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title = "Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice",

abstract = "Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.",

author = "Tiffany Hensley-McBain and Orr, \{Miranda E.\}",

note = "Publisher Copyright: {\textcopyright} 2024",

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AU - Hensley-McBain, Tiffany

AU - Orr, Miranda E.

PY - 2024/12/4

Y1 - 2024/12/4

N2 - Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.

AB - Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.

UR - https://www.scopus.com/pages/publications/85210062253

U2 - 10.1016/j.neuron.2024.10.025

DO - 10.1016/j.neuron.2024.10.025

M3 - Comment/debate

C2 - 39637835

AN - SCOPUS:85210062253

SN - 0896-6273

VL - 112

SP - 3811

EP - 3813

JO - Neuron

JF - Neuron

IS - 23

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Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice

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