Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: Gene-gene interactions in high-risk Indians

Mohammad Yahya Karimi; Vaishali Kapoor; Suresh Chandra Sharma; Satya Narayan Das

doi:10.3109/07357907.2012.743555

Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: Gene-gene interactions in high-risk Indians

Mohammad Yahya Karimi
, Vaishali Kapoor
, Suresh Chandra Sharma
, Satya Narayan Das

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor. The combined genotypes FAS -1377 GA or AA and FASL -844 TT (p <0.03), and FAS -670 AG or GG and FASL -844 TT (p <0.007) appeared to double the risk. FAS and FASL gene-gene and gene-environment interactions seems to modulate susceptibility/resistance to tobacco-related oral cancer in Indians.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Cancer Investigation
Volume	31
Issue number	1
DOIs	https://doi.org/10.3109/07357907.2012.743555
State	Published - Jan 2013

Keywords

FAS
FASL
Indians
Oral cancer
Risk
SNP

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10.3109/07357907.2012.743555

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title = "Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: Gene-gene interactions in high-risk Indians",

abstract = "We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor. The combined genotypes FAS -1377 GA or AA and FASL -844 TT (p <0.03), and FAS -670 AG or GG and FASL -844 TT (p <0.007) appeared to double the risk. FAS and FASL gene-gene and gene-environment interactions seems to modulate susceptibility/resistance to tobacco-related oral cancer in Indians.",

keywords = "FAS, FASL, Indians, Oral cancer, Risk, SNP",

author = "Karimi, \{Mohammad Yahya\} and Vaishali Kapoor and Sharma, \{Suresh Chandra\} and Das, \{Satya Narayan\}",

note = "Funding Information: This work was partly supported by the Indian Council of Medical Research. MYK was recipient of fellowship from DBT and VK from CSIR. The authors report no conflict of interest.",

year = "2013",

month = jan,

doi = "10.3109/07357907.2012.743555",

language = "English",

volume = "31",

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journal = "Cancer Investigation",

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T1 - Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma

T2 - Gene-gene interactions in high-risk Indians

AU - Karimi, Mohammad Yahya

AU - Kapoor, Vaishali

AU - Sharma, Suresh Chandra

AU - Das, Satya Narayan

N1 - Funding Information: This work was partly supported by the Indian Council of Medical Research. MYK was recipient of fellowship from DBT and VK from CSIR. The authors report no conflict of interest.

PY - 2013/1

Y1 - 2013/1

N2 - We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor. The combined genotypes FAS -1377 GA or AA and FASL -844 TT (p <0.03), and FAS -670 AG or GG and FASL -844 TT (p <0.007) appeared to double the risk. FAS and FASL gene-gene and gene-environment interactions seems to modulate susceptibility/resistance to tobacco-related oral cancer in Indians.

AB - We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP. In logistic regression analysis FAS -1377 GA genotype appeared to marginally increase the risk while FASL -844 TC genotype appeared as low risk factor. The combined genotypes FAS -1377 GA or AA and FASL -844 TT (p <0.03), and FAS -670 AG or GG and FASL -844 TT (p <0.007) appeared to double the risk. FAS and FASL gene-gene and gene-environment interactions seems to modulate susceptibility/resistance to tobacco-related oral cancer in Indians.

KW - FAS

KW - FASL

KW - Indians

KW - Oral cancer

KW - Risk

KW - SNP

UR - https://www.scopus.com/pages/publications/84872741300

U2 - 10.3109/07357907.2012.743555

DO - 10.3109/07357907.2012.743555

M3 - Article

C2 - 23153021

AN - SCOPUS:84872741300

SN - 0735-7907

VL - 31

SP - 1

EP - 6

JO - Cancer Investigation

JF - Cancer Investigation

IS - 1

ER -

Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: Gene-gene interactions in high-risk Indians

Abstract

Keywords

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