TY - JOUR
T1 - Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women
AU - Munn-Chernoff, Melissa A.
AU - Grant, Julia D.
AU - Agrawal, Arpana
AU - Sartor, Carolyn E.
AU - Werner, Kimberly B.
AU - Bucholz, Kathleen K.
AU - Madden, Pamela A.F.
AU - Heath, Andrew C.
AU - Duncan, Alexis E.
N1 - Funding Information:
This work was supported by NIH grants: R01 DA023668 and R21 AA021235 (AA); K08 AA017921 (CES); and R01 HD049024 , R01 AA009022 , R01 AA017915 , R01 AA021492 , R37 AA007728 , P60 AA011988 , and K05 AA017688 (ACH). MMC was supported by National Institute of Alcohol Abuse and Alcoholism T32 AA007580 (ACH) and KBW was supported by National Institute of Drug Abuse T32 DA015035 (Cunningham-Williams). CES was also supported by a grant from the Robert E. Leet and Clara Guthrie Patterson Trust . The NIH had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background: Despite substantial evidence that alcohol use disorder (AUD) and bulimic behaviors (i.e., binge eating and compensatory behaviors) co-occur, insufficient information exists regarding a possible shared etiology. Moreover, although numerous twin studies of European ancestry individuals have reported moderate heritability estimates for AUD and bulimic behaviors, with little evidence for shared environmental factors, research on genetic and environmental risk in African American (AA) individuals is lacking. Methods: We investigated specific and overlapping genetic and environmental influences on AUD and bulimic behaviors in 3232 European American (EA; 55.38% monozygotic) and 549 AA (42.81% monozygotic) young adult female twins from the Missouri Adolescent Female Twin Study (age range = 18-29 years). A structured clinical interview assessed lifetime DSM-5 AUD (minus craving) and bulimic behaviors. Biometrical twin modeling was conducted to generate age-adjusted estimates of genetic and environmental influences on AUD, bulimic behaviors, and their comorbidity. Results: Estimates of genetic and environmental contributions on AUD and bulimic behaviors could be equated across EA and AA women. Additive genetic effects accounted for 59% (95% CI: 50%, 66%) and 43% (33%, 52%) of the variance in AUD and bulimic behaviors, respectively, with the remainder due to non-shared environmental effects. Shared genetic factors (rg=33 (18, .49)) were solely responsible for the correlation between phenotypes; the non-shared environmental correlation was not significant (re=10 (-05, .25)). Conclusions: Findings indicate similar magnitudes of genetic and environmental effects on AUD and bulimic behaviors for EA and AA women and implicate common genetic mechanisms underlying liability to these problem behaviors.
AB - Background: Despite substantial evidence that alcohol use disorder (AUD) and bulimic behaviors (i.e., binge eating and compensatory behaviors) co-occur, insufficient information exists regarding a possible shared etiology. Moreover, although numerous twin studies of European ancestry individuals have reported moderate heritability estimates for AUD and bulimic behaviors, with little evidence for shared environmental factors, research on genetic and environmental risk in African American (AA) individuals is lacking. Methods: We investigated specific and overlapping genetic and environmental influences on AUD and bulimic behaviors in 3232 European American (EA; 55.38% monozygotic) and 549 AA (42.81% monozygotic) young adult female twins from the Missouri Adolescent Female Twin Study (age range = 18-29 years). A structured clinical interview assessed lifetime DSM-5 AUD (minus craving) and bulimic behaviors. Biometrical twin modeling was conducted to generate age-adjusted estimates of genetic and environmental influences on AUD, bulimic behaviors, and their comorbidity. Results: Estimates of genetic and environmental contributions on AUD and bulimic behaviors could be equated across EA and AA women. Additive genetic effects accounted for 59% (95% CI: 50%, 66%) and 43% (33%, 52%) of the variance in AUD and bulimic behaviors, respectively, with the remainder due to non-shared environmental effects. Shared genetic factors (rg=33 (18, .49)) were solely responsible for the correlation between phenotypes; the non-shared environmental correlation was not significant (re=10 (-05, .25)). Conclusions: Findings indicate similar magnitudes of genetic and environmental effects on AUD and bulimic behaviors for EA and AA women and implicate common genetic mechanisms underlying liability to these problem behaviors.
KW - African American
KW - Alcohol use disorder
KW - DSM-5
KW - Eating disorders
KW - Heritability
KW - Twins
UR - http://www.scopus.com/inward/record.url?scp=84937629813&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2015.05.043
DO - 10.1016/j.drugalcdep.2015.05.043
M3 - Article
C2 - 26096536
AN - SCOPUS:84937629813
VL - 153
SP - 335
EP - 340
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
ER -