@article{85f76679be13468a81df58c827adcadb,
title = "Genetic Modifiers of the Breast Tumor Microenvironment",
abstract = "Multiple nonmalignant cell types in the tumor microenvironment (TME) impact breast cancer risk, metastasis, and response to therapy, yet most heritable mechanisms that influence TME cell function and breast cancer outcomes are largely unknown. Breast cancer risk is ∼30% heritable and >170 genetic loci have been associated with breast cancer traits. However, the majority of candidate genes have poorly defined mechanistic roles in breast cancer biology. Research indicates that breast cancer risk modifiers directly impact cancer cells, yet it is equally plausible that some modifier alleles impact the nonmalignant TME. The objective of this review is to examine the list of current breast cancer candidate genes that may modify breast cancer risk and outcome through the TME.",
keywords = "angiogenesis, breast cancer, consomic, genetic, tumor microenvironment",
author = "Flister, {Michael J.} and Carmen Bergom",
note = "Funding Information: We apologize to the authors whose work was not cited due to space limitations. This work was supported by a seed grant from the Wisconsin Breast Cancer Showhouse, the MCW Cancer Center, the Advancing a Healthier Wisconsin Endowment, and the Dr. Nancy Sobczak Fund for Breast Cancer (M.J.F and C.B.). Support was also received from the NCI (R01CA193343 (M.J.F)); the Mary Kay Foundation [Grant No. 024-16 (M.J.F) and 017-29 (C.B.)]; a Susan G. Komen Grant #CCR17483233 (C.B.); an American Cancer Society Institutional Research Grant [#86-004-26 (C.B.)]; and the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Office of the Director of the NIH via the Clinical & Translational Science Institute [#8KL2TR000056 (C.B.)]. Funding Information: We apologize to the authors whose work was not cited due to space limitations. This work was supported by a seed grant from the Wisconsin Breast Cancer Showhouse , the MCW Cancer Center , the Advancing a Healthier Wisconsin Endowment , and the Dr. Nancy Sobczak Fund for Breast Cancer (M.J.F and C.B.). Support was also received from the NCI ( R01CA193343 (M.J.F)); the Mary Kay Foundation [Grant No. 024-16 (M.J.F) and 017-29 (C.B.)]; a Susan G. Komen Grant #CCR17483233 (C.B.); an American Cancer Society Institutional Research Grant [ #86-004-26 (C.B.)]; and the National Center for Research Resources , the National Center for Advancing Translational Sciences , and the Office of the Director of the NIH via the Clinical & Translational Science Institute [ #8KL2TR000056 (C.B.)]. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = jun,
doi = "10.1016/j.trecan.2018.04.003",
language = "English",
volume = "4",
pages = "429--444",
journal = "Trends in Cancer",
issn = "2405-8033",
number = "6",
}