Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling

Toru Oka, Jian Xu, Robert A. Kaiser, Jaime Melendez, Michael Hambleton, Michelle A. Sargent, Angela Lorts, Eric W. Brunskill, Gerald W. Dorn, Simon J. Conway, Bruce J. Aronow, Jeffrey Robbins, Jeffery D. Molkentin

Research output: Contribution to journalArticlepeer-review

400 Scopus citations


The cardiac extracellular matrix is a dynamic structural support network that is both influenced by, and a regulator of, pathological remodeling and hypertrophic growth. In response to pathologic insults, the adult heart reexpresses the secreted extracellular matrix protein periostin (Pn). Here we show that Pn is critically involved in regulating the cardiac hypertrophic response, interstitial fibrosis, and ventricular remodeling following long-term pressure overload stimulation and myocardial infarction. Mice lacking the gene encoding Pn (Postn) were more prone to ventricular rupture in the first 10 days after a myocardial infarction, but surviving mice showed less fibrosis and better ventricular performance. Pn mice also showed less fibrosis and hypertrophy following long-term pressure overload, suggesting an intimate relationship between Pn and the regulation of cardiac remodeling. In contrast, inducible overexpression of Pn in the heart protected mice from rupture following myocardial infarction and induced spontaneous hypertrophy with aging. With respect to a mechanism underlying these alterations, Pn hearts showed an altered molecular program in fibroblast function. Indeed, fibroblasts isolated from Pn hearts were less effective in adherence to cardiac myocytes and were characterized by a dramatic alteration in global gene expression (7% of all genes). These are the first genetic data detailing the function of Pn in the adult heart as a regulator of cardiac remodeling and hypertrophy.

Original languageEnglish
Pages (from-to)313-321
Number of pages9
JournalCirculation research
Issue number3
StatePublished - Aug 2007


  • Cardiac
  • Hypertrophy
  • Mouse genetics
  • Remodeling
  • Signaling


Dive into the research topics of 'Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling'. Together they form a unique fingerprint.

Cite this