Abstract
High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have contructed a genetic map of chromosome 7 with 64 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed miltilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.
Original language | English |
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Pages (from-to) | 8006-8010 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 84 |
Issue number | 22 |
DOIs | |
State | Published - 1987 |