Genetic linkage map of human chromosome 7 with 63 DNA markers

D. Barker; P. Green; R. Knowlton; J. Schumm; E. Lander; A. Oliphant; H. Willard; G. Akots; V. Brown; T. Gravius; C. Helms; C. Nelson; C. Parker; K. Rediker; M. Rising; D. Watt; B. Weiffenbach; H. Donis-Keller

doi:10.1073/pnas.84.22.8006

Genetic linkage map of human chromosome 7 with 63 DNA markers

D. Barker, P. Green, R. Knowlton, J. Schumm, E. Lander, A. Oliphant, H. Willard, G. Akots, V. Brown, T. Gravius, C. Helms, C. Nelson, C. Parker, K. Rediker, M. Rising, D. Watt, B. Weiffenbach, H. Donis-Keller

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Abstract

High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have contructed a genetic map of chromosome 7 with 64 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed miltilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.

Original language	English
Pages (from-to)	8006-8010
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	84
Issue number	22
DOIs	https://doi.org/10.1073/pnas.84.22.8006
State	Published - 1987

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Barker, D., Green, P., Knowlton, R., Schumm, J., Lander, E., Oliphant, A., Willard, H., Akots, G., Brown, V., Gravius, T., Helms, C., Nelson, C., Parker, C., Rediker, K., Rising, M., Watt, D., Weiffenbach, B., & Donis-Keller, H. (1987). Genetic linkage map of human chromosome 7 with 63 DNA markers. Proceedings of the National Academy of Sciences of the United States of America, 84(22), 8006-8010. https://doi.org/10.1073/pnas.84.22.8006

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title = "Genetic linkage map of human chromosome 7 with 63 DNA markers",

abstract = "High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have contructed a genetic map of chromosome 7 with 64 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed miltilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.",

author = "D. Barker and P. Green and R. Knowlton and J. Schumm and E. Lander and A. Oliphant and H. Willard and G. Akots and V. Brown and T. Gravius and C. Helms and C. Nelson and C. Parker and K. Rediker and M. Rising and D. Watt and B. Weiffenbach and H. Donis-Keller",

year = "1987",

doi = "10.1073/pnas.84.22.8006",

language = "English",

volume = "84",

pages = "8006--8010",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Barker, D, Green, P, Knowlton, R, Schumm, J, Lander, E, Oliphant, A, Willard, H, Akots, G, Brown, V, Gravius, T, Helms, C, Nelson, C, Parker, C, Rediker, K, Rising, M, Watt, D, Weiffenbach, B & Donis-Keller, H 1987, 'Genetic linkage map of human chromosome 7 with 63 DNA markers', Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 22, pp. 8006-8010. https://doi.org/10.1073/pnas.84.22.8006

TY - JOUR

T1 - Genetic linkage map of human chromosome 7 with 63 DNA markers

AU - Barker, D.

AU - Green, P.

AU - Knowlton, R.

AU - Schumm, J.

AU - Lander, E.

AU - Oliphant, A.

AU - Willard, H.

AU - Akots, G.

AU - Brown, V.

AU - Gravius, T.

AU - Helms, C.

AU - Nelson, C.

AU - Parker, C.

AU - Rediker, K.

AU - Rising, M.

AU - Watt, D.

AU - Weiffenbach, B.

AU - Donis-Keller, H.

PY - 1987

Y1 - 1987

N2 - High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have contructed a genetic map of chromosome 7 with 64 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed miltilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.

AB - High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have contructed a genetic map of chromosome 7 with 64 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed miltilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.

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U2 - 10.1073/pnas.84.22.8006

DO - 10.1073/pnas.84.22.8006

M3 - Article

C2 - 2891136

AN - SCOPUS:0023626634

SN - 0027-8424

VL - 84

SP - 8006

EP - 8010

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 22

ER -

Genetic linkage map of human chromosome 7 with 63 DNA markers

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