Genetic linkage map of human chromosome 7 with 63 DNA markers

D. Barker, P. Green, R. Knowlton, J. Schumm, E. Lander, A. Oliphant, H. Willard, G. Akots, V. Brown, T. Gravius, C. Helms, C. Nelson, C. Parker, K. Rediker, M. Rising, D. Watt, B. Weiffenbach, H. Donis-Keller

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have contructed a genetic map of chromosome 7 with 64 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed miltilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.

Original languageEnglish
Pages (from-to)8006-8010
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
StatePublished - 1987


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