Genetic issues in pediatric pancreatitis

Leena Kandula, David C. Whitcomb, Mark E. Lowe

Research output: Contribution to journalReview article

15 Scopus citations


The number of hospitalizations in children with acute and chronic pancreatitis is increasing and accounts for significant morbidity. Acute pancreatitis is a reversible event involving diffuse inflammation of the pancreas with variable involvement of other regional tissues, remote organs, or both, whereas chronic pancreatitis is a process that produces irreversible changes in the pancreatic structure and function. Mutations in the gene encoding cationic trypsinogen have recently been identified to be associated with hereditary pancreatitis. Genetic mutations in the pancreatic secretory trypsin inhibitor and the cystic fibrosis transmembrane conductance regulator have been described to play a role in the development of pancreatitis as well. Mutations in the cytokine target genes relating to regulation of inflammation are likely to be important in determining the severity of pancreatitis. These findings, along with the advances in cell biology, have contributed to a better understanding of the pathophysiology of pancreatic diseases.

Original languageEnglish
Pages (from-to)248-253
Number of pages6
JournalCurrent gastroenterology reports
Issue number3
StatePublished - Jun 1 2006
Externally publishedYes

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