Genetic interactions between transcription factors cause natural variation in yeast

Justin Gerke, Kim Lorenz, Barak Cohen

Research output: Contribution to journalArticlepeer-review

143 Scopus citations

Abstract

Our understanding of the genetic basis of phenotypic diversity is limited by the paucity of examples in which multiple, interacting loci have been identified. We show that natural variation in the efficiency of sporulation, the program in yeast that initiates the sexual phase of the life cycle, between oak tree and vineyard strains is due to allelic variation between four nucleotide changes in three transcription factors: IME1, RME1, and RSF1. Furthermore, we identified that selection has shaped quantitative variation in yeast sporulation between strains. These results illustrate how genetic interactions between transcription factors are a major source of phenotypic diversity within species.

Original languageEnglish
Pages (from-to)498-501
Number of pages4
JournalScience
Volume323
Issue number5913
DOIs
StatePublished - Jan 23 2009

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